Results 91 to 100 of about 302,567 (313)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Multi-variate image analysis for detection of biomedical anomalies [PDF]

Multi-modal images are commonly used in the field of medicine for anomaly detection, for example CT/MRI images for tumour detection. Recently, thermal imaging has demonstrated its potential for detection of anomalies (e.g., water stress, disease) in ...
Raza, Shan-e-Ahmed
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Seasonal mastitis assessment in Holstein Friesian Crossbred cows using infrared thermography

Italian Journal of Animal Science
Mastitis remains a major challenge in the dairy sector, causing significant economic losses and impacting animal welfare globally. Early detection of sub-clinical (SCM) and clinical mastitis (CM) is crucial for effective management, particularly in ...
S. L. Gayathri, M. Bhakat, T. K. Mohanty
doaj   +1 more source

Novel Entropy for Enhanced Thermal Imaging and Uncertainty Quantification

Entropy
This paper addresses the critical need for precise thermal modeling in electronics, where temperature significantly impacts system reliability. We emphasize the necessity of accurate temperature measurement and uncertainty quantification in thermal ...
Hrach Ayunts, Artyom Grigoryan, Sos Agaian   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Thermal Modelling of the Ventilation and Cooling inside Axial Flux Permanent Magnet Generators [PDF]

, 2010
Axial flux permanent magnet generators are of particular interest for power generation in harsh and confined conditions. Due to their compactness and high power density, the ventilation and cooling inside axial flux permanent magnet generators have ...
LIM, CHIN,HONG, Lim, Chin Hong
core  

Fire Science Living Lab for Flashover Prediction

Proceedings, 2019
There is a huge demand for new techniques and technologies to tackle life-threatening in fire emergencies. Enclosure fires are a type of emergency involving firefighters whose lives are sometimes put at risk.
Daniel Cortés, David Gil, Jorge Azorín
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Detecting Moving Wildlife Using the Time Difference between Two Thermal Airborne Images

Remote Sensing
Wildlife damage to agriculture is serious in Japan; therefore, it is important to understand changes in wildlife population sizes. Although several studies have been conducted to detect wildlife from drone images, behavioral changes (such as wildlife ...
Yu Oishi, Natsuki Yoshida, Hiroyuki Oguma   +2 more
doaj   +1 more source