Results 31 to 40 of about 149,890 (261)

Parameter-Matching Algorithm and Optimization of Integrated Thermal Management System of Aircraft

Aerospace, 2022
The integrated thermal management system of aircraft is essential to maintain a suitable environment for the cabin crew and devices. The system is composed of the air-cycle refrigeration subsystem, the vapor-compression refrigeration subsystem, the ...
Ri Wang, Sujun Dong, Hongsheng Jiang, Peiru Li, Hainan Zhang   +4 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Control Strategy for Helicopter Thermal Management System Based on Liquid Cooling and Vapor Compression Refrigeration

Energies, 2020
With the continuous application of high-power electronic equipment in aircraft, highly efficient heat transfer technology has been emphasized for airborne applications. In this paper, a thermal management system based on an antifreeze liquid cooling loop
Miao Zhao, Liping Pang, Meng Liu, Shizhao Yu, Xiaodong Mao   +4 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Development of a Hydrogen Fuel Cell Hybrid Urban Air Mobility System Model Using a Hydrogen Metal Hydride Tank

Energies
Hydrogen fuel cell-based UAM (urban air mobility) systems are gaining significant attention due to their advantages of higher energy density and longer flight durations compared to conventional battery-based UAM systems.
Sanghyun Yun, Seok Yeon Im, Jaeyoung Han
doaj   +1 more source

A Study on Thermal Management Systems for Hybrid–Electric Aircraft

Aerospace, 2023
The electrification of an aircraft’s propulsive system is identified as a potential solution towards a lower carbon footprint in the aviation industry. One of the effects of increased electrification is the generation of a large amount of waste heat that
Maria Coutinho, Frederico Afonso, Alain Souza, David Bento, Ricardo Gandolfi, Felipe R. Barbosa, Fernando Lau, Afzal Suleman   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Review on Thermal Behaviors and Thermal Management Systems for Supercapacitors

Batteries, 2023
As a representative electrochemical energy storage device, supercapacitors (SCs) feature higher energy density than traditional capacitors and better power density and cycle life compared to lithium-ion batteries, which explains why they are extensively ...
Wei Zhou, Zhien Liu, Wan Chen, Xianzhong Sun, Maji Luo, Xiaohu Zhang, Chen Li, Yabin An, Shuang Song, Kai Wang, Xiong Zhang   +10 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source