Results 61 to 70 of about 4,227,955 (306)

Effect of substrate thermal resistance on space-domain microchannel [PDF]

, 2009
In recent years, Fluorescent Melting Curve Analysis (FMCA) has become an almost ubiquitous feature of commercial quantitative PCR (qPCR) thermal cyclers. Here a micro-fluidic device is presented capable of performing FMCA within a microchannel.
Dalton, Tara, Kinahan, David J., Davies, Mark   +2 more
core   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Modeling of Thermal Contact Resistance of Ball Screws Considering the Load Distribution of Balls

, 2021
A new analytical method for the modeling of the thermal contact resistance of ball screws considering the load distribution of balls is proposed in this research.
Zan, Tao, Gao, Xiangsheng, Li, Qi, Wang, Min, Ma, Jiqian   +4 more
core   +2 more sources

THE EFFECT OF THERMAL RESISTANCE OF CEILING LAYER ON THE PERFORMANCE OF AN AIR CONDITIONER AND ROOM TEMPERATURE DISTRIBUTION

Rekayasa Mesin
The effectiveness of an air conditioner does not only depend on the design of the air-conditioner solely. Several factors affect the effectiveness of the cooling process of a room.
Jeri Tangalajuk Siang, Daud Patabang
doaj   +1 more source

Numerical Thermal Analysis and Optimization of Multi-Chip LED Module Using Response Surface Methodology and Genetic Algorithm

IEEE Access, 2017
In this paper, the heat transfer performance of the multi-chip (MC) LED module is investigated numerically by using a general analytical solution. The configuration of the module is optimized with genetic algorithm (GA) combined with a response surface ...
Hong-Yu Tang, Huai-Yu Ye, Xian-Ping Chen, Cheng Qian, Xue-Jun Fan, Guo-Qi Zhang   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Influence of geometric factors on the heat transfer characteristics of two-phase thermosyphons

Технологія та конструювання в електронній апаратурі
Thermosyphons are two-phase closed heat exchange systems that contain a certain amount of liquid and utilize the latent heat of vaporization and condensation to transfer heat between the heat source and the heat sink without any external devices.
Volodymyr Kravets, Hanna Shepel, Dmytro Hurov, Andrii Danylovich   +3 more
doaj   +1 more source

The investigation of quality of power-transistor crystals soldering by a transient impedance-spectrometer [PDF]

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2012
Differential distribution profiles of the thermal «junction-to-case» resistance of KP723G transistors in accordance with the attachment of the crystals into the package have been investigated.
Turtsevich А. S., Rubtsevich I. I., Solov’yov Ya. А., Vas’kov O. S., Kononenko V. К., Niss V. S., Kerentsev А. F.   +6 more
doaj