Results 81 to 90 of about 402,137 (316)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Technique and setup for diagnostics of p-n junction–package thermal resistance in high-power gallium nitride LEDs

, 2012
We present a setup and procedure of studying p-n junction–package thermal resistance in high-power light-emitting diodes (LEDs) from their thermal relaxation. A set of LEDs mounted on a metal-core printed circuit board (MCPCB) were studied.
Kudryk Y. Y., Konakova R. V., Zinovchuk A. V., Sorokіn V. М.   +3 more
core  

Thermal response testing through the chalk aquifer

, 2013
Thermal conductivity of the ground is an important parameter in the design of ground energy systems, which have an increasing role to play in providing renewable heat to the built environment.
Powrie, W., Powrie, W, Roberts, T, Loveridge, F, Holmes, G, Roberts, T., Holmes, G., Loveridge, F.   +7 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Identification of the Building Envelope Performance of a Residential Building: A Case Study

Energies, 2020
Since households are one of the most energy-intensive sectors in Europe, retrofit of dwellings is promoted to increase energy efficiency. Recent research, however, shows that the energy performance after retrofit does not always meet the target values ...
Evi Lambie, Dirk Saelens
doaj   +1 more source

Enhanced thermal resistance of rammed earth blocks with recycled industry by-products

, 2019
Design, construction and operation of built environments emit 40% of global anthropogenic greenhouse gases. Search for alternative building materials is imperative for ensuring sustainable habitat for world's increasing population.
Porter, Hannah, Jain, Deepak, Mukherjee, Abhijit, Blake, Joshua   +3 more
core   +1 more source

Influence of coating on the thermal resistance of a Ni-Based superalloy [PDF]

, 2006
In this paper, the influence of M-CrAlY polycrystalline coating on the thermal fatigue behavior of a Nickel-base superalloy has been investigated. A special device using a rotating bending machine and two thermal sources has been used to perform thermo ...
Stephan, Nicolas, Chieragatti, Rémy, Mabru, Catherine   +2 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Thermal Characteristics of Staggered Double-Layer Microchannel Heat Sink

Entropy, 2018
The present work numerically studies the thermal characteristics of a staggered double-layer microchannel heat sink (DLMCHS) with an offset between the upper layer of microchannels and lower layer of microchannels in the width direction, and investigates
Dalei Jing, Lei He
doaj   +1 more source

Analysis of the Impact of Building Integrated Photovoltaics (BIPV) on Reducing the Demand for Electricity and Heat in Buildings Located in Poland

Energies, 2020
Based on a method to reduce energy consumption suggested in a real energy audit carried out in an industrial plant located in Poznań (city in Poland), the potential of using photovoltaic (PV) panels as wall cladding was analyzed, in order to reduce ...
Arkadiusz Dobrzycki, Dariusz Kurz, Stanisław Mikulski, Grzegorz Wodnicki   +3 more
doaj   +1 more source