Results 61 to 70 of about 28,108 (259)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Experimental study on overall and local thermal comfort under different radiation intensities [PDF]

E3S Web of Conferences
Shortwave radiation constitutes the principal source of thermal loading within automobile cabins, exhibiting characteristics of transient change and non-uniform distribution.
Zeng Yingqi, Zhou Xiang, Zhai Yongchao, Xia Haifeng   +3 more
doaj   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Models and Indicators to Assess Thermal Sensation Under Steady-state and Transient Conditions

Energies, 2019
The assessment of thermal sensation is the first stage of many studies aimed at addressing thermal comfort and at establishing the related criteria used in indoor and outdoor environments. The study of thermal sensation requires suitable modelling of the
Diana Enescu
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Effects of solar radiation on human thermal comfort under different activity intensities —— a chamber study

Journal of Asian Architecture and Building Engineering
Global warming and accelerated urbanization have exposed urban residents to more severe threats of heat waves and extreme high temperatures. During daily commuting, people are inevitably exposed to solar radiation environments, enduring prolonged direct ...
Xin Wu, Aimei Luo, Chaopu Yuan, Xiaofang Lu, Meng Zhen, Yu Shao, Qi Dong, Guangmeng Bian   +7 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

On Thermal Sensation and Entropy

, 1995
A neurophysiological thesis is proposed for thermal sensitivity that accounts for the disorder in physical processes that is fundamental to temperature. There is likely some form of thermal equilibrium rapidly established between thermoreceptors and the external environment local to those thermoreceptors that accounts for gauging the temperature ...
openaire   +3 more sources

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Adaptive Thermal Comfort and Skin Moisture Sensation of Occupants During Summer in Naturally Ventilated Urban Dwellings with the Potential to Lower Cooling Energy Demand

Energies
Adaptive thermal comfort is essential for understanding occupants’ responses to indoor thermal environments in residential buildings. However, field studies on adaptive thermal comfort in urban dwellings in Nepal remain limited, and the influence of skin
Sanjiv Shrestha, Hom Bahadur Rijal
doaj   +1 more source