Results 51 to 60 of about 2,023,540 (205)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Dopamine regulates approach-avoidance in human sensation-seeking. [PDF]

, 2015
Background Sensation-seeking is a trait that constitutes an important vulnerability factor for a variety of psychopathologies with high social cost.
Roiser, JP, Winston, J., Roiser, J., Kurth-Nelson, Z, Husain, M., Kurth-Nelson, Z. ; https://orcid.org/, Norbury, A, Husain, M, ,, Norbury, A., Winston, JS   +10 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Determinación de los intervalos de confort y estrés térmico para espacios abiertos en la ciudad de Maringá (PR), Brasil, utilizando el índice PET

Desenvolvimento e Meio Ambiente, 2019
Prediction models of thermal comfort in open spaces are considered a fundamental tool in neighborhood planning, as well as in open space design within urban areas. However, most of these indices were developed for cold climates.
Mirna Milena Aquino, Paulo Fernando Soares, Carolina Lotufo Bueno-Bartolomei   +2 more
doaj   +1 more source

The use of a thermophysiological model in the built environment to predict thermal sensation : coupling with the indoor environment and thermal sensation

, 2013
Thermal comfort, influenced by thermal sensation is an important building performance indicator. In this study we discuss the use of a thermophysiological model in the built environment to assess thermal sensation. In the context of this work, the use of
Loomans, M.G.L.C., Kingma, B.R.M., Marken Lichtenbelt, van, W.D., Wit, de, M.H., Frijns, A.J.H.; id_orcid, Schellen, L.   +5 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Spatial structure of Yangzhou’ s old public bathrooms: a space syntax analysis of the topological characteristics of their unique sensory space

Journal of Asian Architecture and Building Engineering, 2023
Sensory experience is vital in creating a local identity in historical buildings and should ideally be conserved along with basic spatial structure. Hence, this study explores the relation between the spatial structure and thermal sensation experience by
Xing Chen, Wangteng Duan, Yi Liu, Shengcai Li, Shunyu Sui   +4 more
doaj   +1 more source

Challenging the assumptions for thermal sensation scales [PDF]

, 2016
Scales are widely used to assess the personal experience of thermal conditions in built environments. Most commonly, thermal sensation is assessed, mainly to determine whether a particular thermal condition is comfortable for individuals.
Fuchs, Xaver, Dovjak, Mateja, Hawighorst, Maren, Kolarik, Jakub, Fuchs, Xaver ; https://orcid.org/, Schweiker, Marcel, Becker, Susanne, Shukuya, Masanori, Maren Hawighorst   +8 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source