Results 51 to 60 of about 2,092,491 (287)
Atmosphere, 2020 A personalized thermal environment is an effective way to ensure a good thermal sensation for individuals. Since local thermal sensation and temperature distribution are affected by individual physiological differences, it is necessary to study the ...
Shuai He +4 more
doaj +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Assessment of Thermal Environment in a Kitchen with a New Ventilation System [PDF]
E3S Web of Conferences, 2019 Chinese kitchen environment is usually hot and humid in summer and cold in winter, while housewife spends considerable time there. This investigation developed a new ventilation system for Chinese kitchens to improve thermal comfort level.
Liu Sumei +9 more
doaj +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Desenvolvimento e Meio Ambiente, 2019 Prediction models of thermal comfort in open spaces are considered a fundamental tool in neighborhood planning, as well as in open space design within urban areas. However, most of these indices were developed for cold climates.
Mirna Milena Aquino +2 more
doaj +1 more source
Thermal sensations of secondary schoolchildren in summer [PDF]
Journal of Hygiene, 1973 SUMMARYSummer thermal sensations of secondary schoolchildren in England are compared with those earlier published for winter. Heat stress, contrary to expectation, is seen to decrease during the warm months, and neutrality is found to increase by some 6° F.
openaire +4 more sources
Local thermal sensation with varying clothing insulation
, 2022 Paper 1107, 8 S.In the present study the local thermal sensation of subjects as well as the impact of local thermal sensation on the overall thermal sensation was investigated. Two different clothing insulations were compared. The aim of the study was to
Holm, A. +4 more
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