Results 61 to 70 of about 1,935,804 (286)

Thermal comfort based fuzzy logic control [PDF]

, 2001
Most heating, ventilation and air conditioning (HVAC) control systems are considered as temperature control problems. In this work, the predicted mean vote (PMV) is used to control the indoor temperature of a space by setting it at a point where the PMV ...
Underwood, Chris, Danaher, Sean, Gouda, M. M.   +2 more
core   +1 more source

A Thermal Comfort Evaluation Model for Contact Heat Transfer Based on Thermophysiology [PDF]

E3S Web of Conferences
This study integrates the Joint System Thermoregulation Model (JOS) with four different thermal sensation models to establish a thermophysiological-thermal sensation computational framework capable of handling complex contact heat transfer scenarios. The
Song Linye, Xia Haifeng, Zhou Xiang, Zeng Yingqi, Zhang Shuming   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Influence of Internal Structure and Composition on Head’s Local Thermal Sensation and Temperature Distribution

Atmosphere, 2020
A personalized thermal environment is an effective way to ensure a good thermal sensation for individuals. Since local thermal sensation and temperature distribution are affected by individual physiological differences, it is necessary to study the ...
Shuai He, Yinghua Zhang, Zhian Huang, Ge Zhang, Yukun Gao   +4 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Assessment of Thermal Environment in a Kitchen with a New Ventilation System [PDF]

E3S Web of Conferences, 2019
Chinese kitchen environment is usually hot and humid in summer and cold in winter, while housewife spends considerable time there. This investigation developed a new ventilation system for Chinese kitchens to improve thermal comfort level.
Liu Sumei, Zhou Xiaojie, Liu Xuan, Lin Xiaorui, Qing Ke, Zhang Weizhen, Li Jian, Dong Jiankai, Lai Dayi, Chen Qingyan   +9 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Determination of thermal sensation on transient conditions [PDF]

, 2015
The objective of this study is to investigate the difference in thermal environment and human response between air-conditioned closed space and a semi-open space. The thermal response of the subjects in transitional space as they experienced step changes
Gital, Yakubu Y., Hussein, Mohd Kher, Dahlan, Nur Dalilah   +2 more
core   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source