Results 41 to 50 of about 115,304 (302)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Lattice Boltzmann Methods for thermal flows: continuum limit and applications to compressible Rayleigh-Taylor systems [PDF]

, 2010
We compute the continuum thermo-hydrodynamical limit of a new formulation of lattice kinetic equations for thermal compressible flows, recently proposed in [Sbragaglia et al., J. Fluid Mech. 628 299 (2009)].
Biferale, Luca, Sbragaglia, Mauro, Scagliarini, Andrea, Sugiyama, Kazuyasu, Toschi, Federico   +4 more
core   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Influence of Cold Water Inlets and Obstacles on the Energy Efficiency of the Hot Water Production Process in a Hot Water Storage Tank

Energies, 2021
Domestic hot water preparation is one of the main sources of energy consumption in households. One of the most important elements of domestic hot water (DHW) preparation installation is the storage tank. Its design can significantly affect the efficiency
Agnieszka Malec, Tomasz Cholewa, Alicja Siuta-Olcha   +2 more
doaj   +1 more source

Diurnal cycle RANS simulations applied to wind resource assessment [PDF]

, 2019
Microscale computational fluid dynamics (CFD) models can be used for wind resource assessment on complex terrains. These models generally assume neutral atmospheric stratification, an assumption that can lead to inaccurate modeling results and to large ...
Apsley, Avila, Avila, Ayotte, Castro, Chen, Dudhia, Gargallo-Peiró, Gargallo-Peiró, Hong, Houzeaux, Hristov, Janjic, Kain, Koblitz, Kumar, Mlawer, Monin, Palma, Panofsky, Pieterse, Sanz-Rodrigo, Sogachev, Svensson, Taylor, Veiga-Rodrigues, Vázquez   +26 more
core   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Numerical simulation of thermal stratification phenomenon in stagnant branch pipe of pressurized water reactors

He jishu
BackgroundIn thermal pipelines of nuclear power systems, thermal stratification is a common phenomenon that can cause stress concentration and deformation of pipeline structures, thereby leading to safety hazards.
MA Jingxiang, DONG Shichang, GONG Shengjie   +2 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Outer Core Stratification From the High Latitude Structure of the Geomagnetic Field

Frontiers in Earth Science, 2018
The presence of stable stratification has broad implications for the thermal and compositional state of the outer core, the evolution of Earth's deep interior, and the energetics of the geodynamo.
Peter Olson, Peter Olson, Maylis Landeau, Maylis Landeau, Evan Reynolds, Evan Reynolds   +5 more
doaj   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source