Results 71 to 80 of about 20,145 (265)

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Impact of thermal stratification on airborne transmission risk of SARS-CoV-2 in various indoor environments. [PDF]

Build Simul, 2023
Liu F, Luo Z, Qian H.
europepmc   +1 more source

PM10 Impairs CD56dim NK Cell Cytotoxicity via FNBP1 Suppression to Exacerbate Rheumatoid Arthritis: Insights from Multimodal Multi‐Omics

Advanced Science, EarlyView.
This study, through multi‐omics approaches and animal models, revealed that air pollutant PM10 exacerbates the progression of rheumatoid arthritis (RA) by suppressing FNBP1 expression and impairing the cytotoxic function of CD56dim NK cells. The “PM10–FNBP1–NK cells” axis provided novel insights into the environmental pathogenesis of RA and suggested ...
Runhan Zhao, Qinyang Zhang, Yu Jiang, Dagang Tang, Xiao Qu, Jun Zhang, Yi Chen, Weixia Duan, Tao Li, Zhengwei Cai, Yanran Huang, Xiaoji Luo   +11 more
wiley   +1 more source

Numerical Analysis of Hydrogen Behavior Inside Hydrogen Storage Cylinders under Rapid Refueling Conditions Based on Different Shapes of Hydrogen Inlet Ports

Energies
In order to investigate the effects of different shapes of hydrogen inlet ports on the behavioral characteristics of hydrogen in Type IV hydrogen storage cylinders under rapid refueling conditions, a mathematical model of hydrogen temperature rise and a ...
Enhui Zhang, Yangchun Zhao, Jiahui Zhang, Wenchao Wang, Wenhao Yu   +4 more
doaj   +1 more source

Thermal stratification effect on gravity driven transport of hybrid CNTs down a stretched surface through porous medium. [PDF]

Heliyon, 2023
Duraihem FZ, Maraj EN, Akbar NS, Mehmood R.   +3 more
europepmc   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Microclimate Investigation in a Conference Room with Thermal Stratification: An Investigation of Different Air Conditioning Systems

Energies
This paper investigates the microclimate in a conference room with thermal stratification, taking as a case study the chapel of Villa San Saverio, now the seat of the “Scuola Superiore” of the University of Catania (Italy).
Andrea Longhitano, Vincenzo Costanzo, Gianpiero Evola, Francesco Nocera   +3 more
doaj   +1 more source

Analysis of Carreau fluid in the presence of thermal stratification and magnetic field effect

Results in Physics, 2018
In current article theoretical analysis is executed to examine flow features of Carreau fluid by conferring scintillating aspects of thermal stratification.
S. Bilal, Shafqatullah, Ali Saleh Alshomrani, M.Y. Malik, Nabeela Kausar, Farzana Khan, Khalil-ur-Rehman   +6 more
doaj   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

MHD mixed convective stagnation point flow of nanofluid past a permeable stretching sheet with nanoparticles aggregation and thermal stratification. [PDF]

Sci Rep, 2022
Mahmood Z, Alhazmi SE, Alhowaity A, Marzouki R, Al-Ansari N, Khan U.   +5 more
europepmc   +1 more source