Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Compound-Resolved VOC Dynamics in a Full-Scale Medium-Density Fibreboard Dryer: Process-State Screening Across Wood Furnish, Amino Resin Dosing, and Thermal Operating Variables. [PDF]
Polymers (Basel)Nedić V, Paul A, Barbu MC, Kristak L.
europepmc +1 more source
Advanced Science, EarlyView.Intrinsic phase toughening transforms a brittle B2 intermetallic into a plastically deformable, load‐bearing phase, while a heterogeneous laminated architecture suppresses strain localization and interface cracking. The synergy between ductile intermetallics and mesoscale heterogeneity establishes a general design strategy for breaking the long ...
Lu Yang +9 more
wiley +1 more source
Properties and nitrate leaching mitigation effect of thermally treated biomass-a case study of tropical and subtropical islands. [PDF]
Sci RepHamada K, Nakamura S, Yoshida T.
europepmc +1 more source
Advanced Science, EarlyView.Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu +4 more
wiley +1 more source
Phytic Acid and Its Derivatives as Valuable Flame Retardants for Polymer Systems: Current State of the Art and Perspectives. [PDF]
Polymers (Basel)Bifulco A, Malucelli G.
europepmc +1 more source
Surface and Interfacial Engineering toward Durable Mechanically Coupled Flexible Electronics
Advanced Science, EarlyView.This Review highlights how surface and interfacial engineering governs the reliability, durability, and functional stability of mechanically coupled flexible electronics. By integrating fundamental interfacial theory, failure mechanisms, multiscale engineering strategies, and representative applications, it provides a design‐oriented framework for ...
Qian Wang, Fangfang Dai, Wei Wu
wiley +1 more source
Wood-Waste-Based Artificial Aggregates for Extrusion 3D-Printed Cementitious Composites: Hydration, Printability, and Mechanical Performance. [PDF]
Materials (Basel)Kavaliauskienė F +4 more
europepmc +1 more source
Intrinsic Phonons as a Dynamic Control Knob for Catalytic Reactivity in 2D Materials
Advanced Science, EarlyView.Intrinsic phonon excitations are demonstrated to serve as a dynamic control knob for catalytic reactivity in 2D materials. Mode‐selective lattice vibrations reconstruct the electronic structure, lower oxygen evolution reaction barriers, establishing a phonon‐engineering paradigm for dynamically regulating electrocatalysis beyond conventional static ...
Kai Ren +5 more
wiley +1 more source
Saccharide Alterations in Spruce Wood Due to Thermal and Accelerated Aging Processes. [PDF]
Polymers (Basel)Kačík F +5 more
europepmc +1 more source