Results 1 to 10 of about 155,569 (122)

Bioinspired, Guanidinium, and Indole Modified Poly(glycidyl ether)s as Highly Efficient Vectors for Polyplex-Mediated Gene Delivery. [PDF]

Macromol Rapid Commun
Guanidinium‐ and indole‐functionalized poly(glycidyl ether)s were developed as non‐viral gene delivery vectors with tunable hydrophilic–hydrophobic balance. All polymers formed stable DNA polyplexes, while moderate indole content yielded the highest transfection efficiency at low N/P ratios.
Kötzsche M, Dzierza A, Sölter L, Egger J, Cornelis K, Stihl A, Schacher FH, Fischer D, Peneva K.   +8 more
europepmc   +2 more sources

Dual-Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers. [PDF]

Adv Healthc Mater
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Kötzsche M, Dzierza A, Egger J, Rheinberger T, Weilandt C, Wurm FR, Nischang I, Fischer D, Peneva K.   +8 more
europepmc   +2 more sources

Loading of Extracellular Vesicles with Nucleic Acids via Hybridization with Non-Lamellar Liquid Crystalline Lipid Nanoparticles. [PDF]

Adv Sci (Weinh)
This study explores how lipid nanoparticles interact with extracellular vesicles, emphasizing the importance of lipid nanoparticle topology in facilitating a controlled hybridization process between the two nanocarriers. The resulting hybrid nanoparticles display extracellular vesicle membrane proteins on their surface, are loaded with the nucleic acid
Bader J, Rüedi P, Mantella V, Geisshüsler S, Brigger F, Qureshi BM, Ortega Arroyo J, Montanari E, Leroux JC.   +8 more
europepmc   +2 more sources

Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis. [PDF]

Small
Amphiphilic, cationic poly(spermine acrylamides) are synthesized via facile radical polymerization of N‐acryloxysuccinimide and N‐decylacrylamide followed by post‐polymerization functionalization with spermine. In vitro 2D and 3D cell culture, ex vivo and in vivo experiments reveal superior properties of spermine‐copolymers in delivery of siRNA to lung
Adams F, Zimmermann CM, Baldassi D, Pehl TM, Weingarten P, Kachel I, Kränzlein M, Jürgens DC, Braubach P, Alexopoulos I, Wygrecka M, Merkel OM.   +11 more
europepmc   +2 more sources

Mechanism of heat transportation in the intermediate wake of a heated cylinder

Nihon Kikai Gakkai ronbunshu, 2020
The paper clarifies the effects of buoyancy on the mechanism of heat transfer in the wake of heated cylinder for X/D=5-40. Measurements are made by a thermo-anemometer.
Hideaki WATANABE, Hideharu MAKITA, Makoto TAGO   +2 more
doaj   +1 more source

Mechanism of momentum transportation in the intermediate wake of a heated cylinder

Nihon Kikai Gakkai ronbunshu, 2020
Measurements in the wake of a heated cylinder are made by a thermo-anemometer. The purpose is to make clear the effects of buoyancy of heated cylinder on the mechanism of momentum transportation in the wake.
Hideaki WATANABE, Hideharu MAKITA, Makoto TAGO   +2 more
doaj   +1 more source

Development of siRNA and Budesonide Dual‐Loaded Hybrid Lipid–Polymer Nanoparticles by Microfluidics Technology as a Platform for Dual Drug Delivery to Macrophages: An In Vitro Mechanistic Study

Advanced Therapeutics, Volume 6, Issue 8, August 2023., 2023
Macrophage dysregulation in complex diseases requires dual therapeutic approaches. Herein, the development of hybrid nanoparticles coloaded with a model small molecule anti‐inflammatory drug and a model small interfering RNA (siRNA) using microfluidics technology is reported.
Sandra López Cerdá, Flavia Fontana, Shiqi Wang, Alexandra Correia, Giuseppina Molinaro, Rubén Pareja Tello, Jouni Hirvonen, Christian Celia, Goncalo Barreto, Hélder A. Santos   +9 more
wiley   +1 more source

The Effect of Cryoprotectants and Storage Conditions on the Transfection Efficiency, Stability, and Safety of Lipid‐Based Nanoparticles for mRNA and DNA Delivery

Advanced Healthcare Materials, Volume 12, Issue 18, July 17, 2023., 2023
In this study, the impact of storage conditions and the use of cryoprotectants on the medium‐term preservation of lipid‐based nanocarriers is investigated. Nanoparticle stability appears to be directly related to temperature, use of cryoprotectants and type of encapsulated nucleic acid cargo. The effect of storage on the physicochemical characteristics,
Konstantinos N. Kafetzis, Natalia Papalamprou, Elisha McNulty, Kai X. Thong, Yusuke Sato, Aleksandr Mironov, Atul Purohit, Philip J. Welsby, Hideyoshi Harashima, Cynthia Yu‐Wai‐Man, Aristides D. Tagalakis   +10 more
wiley   +1 more source

Synthesis and Application of Low Molecular Weight PEI‐Based Copolymers for siRNA Delivery with Smart Polymer Blends

Macromolecular Bioscience, Volume 23, Issue 2, February 2023., 2023
Nanoparticle formulations of low molecular weight PEI (LMW‐PEI)‐based copolymers PEI‐PCL (800 Da‐40 kDa) and PEI‐PCL‐PEI (5 kDa‐5 kDa‐5 kDa) blended with or without PEG‐PCL (5 kDa‐4 kDa) are prepared using a solvent displacement method with sizes around 100 nm.
Yao Jin, Friederike Adams, Judith Möller, Lorenz Isert, Christoph M. Zimmermann, David Keul, Olivia M. Merkel   +6 more
wiley   +1 more source

PLA‐b‐SMA as an Amphiphilic Diblock Copolymer for Encapsulation of Lipophilic Cargo

Macromolecular Chemistry and Physics, Volume 224, Issue 1, January 2023., 2023
The synthesis of poly(lactic acid)‐b‐poly(styrene‐alt‐maleic acid) (PLA‐b‐SMA) via sequential ring opening polymerization and reversible addition‐fragmentation chain transfer polymerization is presented. This polymer has a hydrophilic (SMA) and hydrophobic (PLA) segment, allowing it to undergo nanoprecipitation for the production of nanosphere and ...
Lauren E. Ball, Rueben Pfukwa, Raoni P. Siqueira, Vanessa C. F. Mosqueira, Bert Klumperman   +4 more
wiley   +1 more source