Results 121 to 130 of about 597,056 (294)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Improving Thermo-Physiological Comfort of Polyester/Cotton Knits by Caustic and Cellulases Treatments

AUTEX Research Journal, 2014
Cotton is one of the most commonly used fibres for making knitwear. Some of the limitations of pure cotton knits include their tendency to shrink, relatively limited durability, and poor wash and wear properties.
Nazir Ahsan, Hussain Tanveer, Zia Qummer, Afzal Muhammad Ali   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Analysis of the heat treatment and thermo-chemical treatment influence on the geometrical accuracy of manufactured detail

, 2010
W publikacji przedstawiono analizę wpływu obróbki cieplnej i cieplno-chemicznej na dokładność geometryczną w procesie kształtowania wyrobu. Przedstawiono współrzędnościową technikę pomiarową jako alternatywę dla badań dylatometrycznych.
Augustyniak, M., Grzelka, M.
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Thermo-Chemical Structure of the Lower Mantle: Seismological Evidence and Consequences for Geodynamics

, 2007
We combine recent progress in seismic tomography and numerical modeling of thermo-chemical convection to infer robust features on mantle structure and dynamics.
Paul J. Tackley, Frédéric Deschamps, Jeannot Trampert   +2 more
core   +1 more source

RESEARCH OF INFLUENCE OF ALLOYING BY BORON ON PROPERTIES THE IRON-CARBON ALLOYS

Литьë и металлургия, 2014
It is shown that for improvement of physical-mechanical properties of the cast products which have hard usage, the boron carbide, which can be used at carrying out process of thermo-chemical treatment of cast products of iron-carbon alloy, is of great ...
K. V. Kobyakov, N. F. Nevar
doaj  

Enhancing thermo-mechanical performance of epoxy composites using alkali-treated almond shells for automotive applications

Journal of Industrial Textiles
Automotive companies are now concentrating on finding new materials that are light, eco-friendly and affordable to help improve fuel economy and lower the industry’s impact on the environment.
Mohammed Ali Hussein, Suhad Dawood Salman   +1 more
doaj   +1 more source