Results 151 to 160 of about 28,286 (323)
Nano Select, EarlyView.Antibacterial micro/nanorobots (MNRs) represent a breakthrough in antibacterial therapy, making precise delivery of drugs to the infection site. This review systematically summarizes the material composition, actuation, and applications of MNRs in combating biofilms and drug‐resistant infections while emphasizing the existing challenges of ...
Yichao Chen +4 more
wiley +1 more source
Small, EarlyView.This work demonstrates a new thermophoretic strategy to fabricate fluorescently labeled stiffness gradient hydrogels, enabling contactless stiffness characterization. Fibroblasts cultured on gradient GelMA and Gellan gum hydrogels revealed distinct cell morphology and migration behavior.
Shin Wei Chong +8 more
wiley +1 more source
Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective
The FEBS Journal, EarlyView.Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska +5 more
wiley +1 more source
SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity
The FEBS Journal, EarlyView.The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl +11 more
wiley +1 more source
The FEBS Journal, EarlyView.Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal +8 more
wiley +1 more source
Thermophoresis and Brownian Model of Pseudo-Plastic Nanofluid Flow over a Vertical Slender Cylinder [PDF]
, 2020 Faizan Hussain, Azad Hussain, S. Nadeem
openalex +1 more source
Collective photo-thermophoresis [PDF]
The stationary distributions of thermally interacting thermophoretic colloids under illumination are studied by mathematical analysis of mean field models. This work generalises the model of Golestanian by explicitly modelling the non-local and non-pairwise effect of shading on the collective dynamics.
openaire
De Novo Design and Synthesis of Novel Benzoxazinone Derivatives Targeting Dihydroxyacid Dehydratase
Plant Biotechnology Journal, EarlyView.ABSTRACT Dihydroxyacid dehydratase (DHAD), a key enzyme in the branched‐chain amino acid (BCAA) synthesis pathway, is a promising herbicide target. Currently, no commercial herbicides target DHAD, and no inhibitors are in development. Structural analysis suggests that coordination with iron–sulfur clusters and hydrophobic interactions with Tyr215 and ...
Bo He +7 more
wiley +1 more source
Numerical modeling tools for chemical vapor deposition [PDF]
Development of general numerical simulation tools for chemical vapor deposition (CVD) was the objective of this study. Physical models of important CVD phenomena were developed and implemented into the commercial computational fluid dynamics software ...
Childs, Edward P., Jasinski, Thomas J.
core +1 more source