Entropy Generation Analysis due to Permeable Exponential Stretching in Boundary Layer Flows
ABSTRACT Entropy generation represents the irreversible loss of useful energy in thermal–fluid systems, directly reducing efficiency in applications, such as microelectronics cooling, nanofluid‐based heat exchangers, and polymer processing. This study investigates entropy generation in a two‐phase viscoelastic nanofluid flow over a permeable ...
Khodani Sherrif Tshivhi +1 more
wiley +1 more source
Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu +9 more
wiley +1 more source
Overcoming PEG Antigenicity: Statistical PEG Isomers Reduce Antibody Binding
Conventional poly(ethylene glycol) (PEG) is commonly applied in biomedicine, but is now known to induce antibody formation. Here, it is shown that the development of “randomized PEG” (rPEG) featuring glycidyl methyl ether (GME) comonomers decreased antibody binding.
Mareike Deuker +5 more
wiley +1 more source
Biomolecular Interaction Determination and Quantification by Microscale Thermophoresis [PDF]
Wyatt Strutz, Govind Shah
openalex +1 more source
Carbon deposition model for oxygen-hydrocarbon combustion. Task 6: Data analysis and formulation of an empirical model [PDF]
The formation and deposition of carbon (soot) was studied in the Carbon Deposition Model for Oxygen-Hydrocarbon Combustion Program. An empirical, 1-D model for predicting soot formation and deposition in LO2/hydrocarbon gas generators/preburners was ...
Makel, Darby B., Rosenberg, Sanders D.
core +1 more source
ABSTRACT The analysis of interactions between biological agents or with surrounding chemicals is important in many areas of modern biochemical, biomedical, and environmental research. Microscale platforms based on affinity chromatography have been shown to be a powerful set of tools for these studies.
David S. Hage +8 more
wiley +1 more source
Heat shock protein 10 as a chaperone modulating α‐synuclein amyloid fibril formation
Abstract HSP10 is a well‐known human co‐chaperone that interacts with HSP60 to comprise the HSP60/10 chaperonin complex which upholds mitochondrial proteostasis. HSP10 also demonstrates independent roles in binding to misfolded proteins and interacts with several amyloidogenic client proteins.
Johan N. K. Larsson +5 more
wiley +1 more source
Microscale Thermophoresis Analysis of Chromatin Interactions
Ivan Corbeski +5 more
openalex +2 more sources
Thermophoresis and thermal orientation of Janus nanoparticles in thermal fields [PDF]
Fernando Bresme +4 more
openalex +1 more source
Human FASTK preferentially binds single‐stranded and G‐rich RNA
Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak +7 more
wiley +1 more source

