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TRP Channels and Thermosensation
2014Several TRP channels exhibit highly temperature-dependent gating properties, which leads to steep changes in depolarising current upon either cooling or heating. Based on this characteristic feature, these so-called "thermoTRPs" have been widely studied with the aim to elucidate their potential key role as thermosensors in the somatosensory system and ...
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Thermosensation and TRP Channels
Somatosensory neurons can sense external temperature by converting sensation of temperature information to neural activity via afferent input to the central nervous system. Various populations of somatosensory neurons have specialized gene expression, including expression of thermosensitive transient receptor potential (TRP) ion channels ...Makoto, Tominaga, Makiko, Kashio
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[Mechanisms Underlying Thermosensation].
Brain and nerve = Shinkei kenkyu no shinpo, 2022The ability to sense ambient temperatures is essential for human survival. Sensory nerve endings contain ion channels that are activated by temperature stimuli, which lead to cation influx and depolarization with consequent action potential generation via activation of voltage-gated Na+ channels.
Makoto, Tominaga, Makiko, Kashio
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Molecular basis of central thermosensation
2018Classic lesion and physiology experiments identified the hypothalamic preoptic area as a pivotal region in the regulation of temperature homeostasis. The preoptic area can sense changes in local temperature, receives information about ambient temperature, contributes to fever, and can affect thermoregulation in response to several biologic signals ...
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Mechanisms of Thermosensation in TRP Channels
2008The transient receptor potential (TRP) superfamily encompasses a large number of cationic channels that are modulated by a wide variety of physical and chemical stimuli. A notorious subgroup of TRP channels, dubbed thermoTRPs, shows a dramatic dependence on temperature, which can be up to tenfold higher than that of classical ionic channels ...
Karel Talavera +2 more
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The neuronal circuits and cellular encoding of thermosensation
Nature Reviews NeuroscienceThe neural circuits processing thermal information play a key role in shaping somatosensory perception, regulating core body temperature and avoiding harm. The circuits underlying thermal perception are less understood than for other sensory systems, but recent research has shed light on the wiring, cellular encoding principles and their link to ...
Mario Carta +2 more
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Thermosensing in hypothalamic osmoregulatory circuits
2013L'homéostasie physiologique est maintenue par l'activation de réponses autonomes et comportementales via l'activité de neurones situés dans l'hypothalamus antérieur. Plus spécifiquement, les cellules magnocellulaires neurosécrétoires (CMNs) situés dans les noyaux périventriculaire et supraoptique relâchent la vasopressine (VP), une hormone peptidique ...
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