Results 31 to 40 of about 1,472 (177)

Cells and circuits for thermosensation in mammals [PDF]

open access: yesNeuroscience Letters, 2019
How is temperature detected and how is the resulting sensory information synthesized to produce appropriate thermosensory responses? Research in the last few years has gone a long way to answering the first part of this question. Excitingly, recent research has uncovered some of the ways sensory inputs are processed spinally, as well as identifying ...
Hans Jürgen, Solinski, Mark A, Hoon
openaire   +2 more sources

The role of TRPA1 channels in thermosensation

open access: yesCell Insight, 2022
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel sensitive to different physical and chemical stimuli. TRPA1 is associated with many important physiological functions in different species and thus is involved in different degrees of evolution.
Hao Zhang   +6 more
openaire   +3 more sources

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

open access: yeseLife, 2016
Venom toxins are invaluable tools for exploring the structure and mechanisms of ion channels. Here, we solve the structure of double-knot toxin (DkTx), a tarantula toxin that activates the heat-activated TRPV1 channel. We also provide improved structures
Chanhyung Bae   +10 more
doaj   +1 more source

Injury Threshold of Oral Contact with Hot Foods and Method for Its Sensory Evaluation

open access: yesSafety, 2018
Epidemiological studies indicate an increased risk of esophageal cancer from the consumption of very hot foods and beverages. The contact time and the contact temperature are decisive for the risk of injury.
Dirk W. Lachenmeier, Walter Lachenmeier
doaj   +1 more source

RNA thermosensors facilitate Streptococcus pneumoniae and Haemophilus influenzae immune evasion.

open access: yesPLoS Pathogens, 2021
Bacterial meningitis is a major cause of death and disability in children worldwide. Two human restricted respiratory pathogens, Streptococcus pneumoniae and Haemophilus influenzae, are the major causative agents of bacterial meningitis, attributing to ...
Hannes Eichner   +6 more
doaj   +1 more source

Transmembrane Prolines Mediate Signal Sensing and Decoding in Bacillus subtilis DesK Histidine Kinase

open access: yesmBio, 2019
Environmental awareness is an essential attribute of all organisms. The homeoviscous adaptation system of Bacillus subtilis provides a powerful experimental model for the investigation of stimulus detection and signaling mechanisms at the molecular level.
Pilar Fernández   +6 more
doaj   +1 more source

Effect of Fluoroalkyl-Substituent in Bistolane-Based Photoluminescent Liquid Crystals on Their Physical Behavior

open access: yesCrystals, 2021
Photoluminescent liquid crystals (PLLCs) have attracted significant attention owing to their broad applicability in thermosensing and PL switching.
Shigeyuki Yamada   +10 more
doaj   +1 more source

What Temperature of Coffee Exceeds the Pain Threshold? Pilot Study of a Sensory Analysis Method as Basis for Cancer Risk Assessment

open access: yesFoods, 2018
The International Agency for Research on Cancer (IARC) evaluates “very hot (>65 °C) beverages” as probably carcinogenic to humans. However, there is a lack of research regarding what temperatures consumers actually perceive as &ldquo ...
Julia Dirler   +2 more
doaj   +1 more source

TREKing noxious thermosensation [PDF]

open access: yesThe EMBO Journal, 2009
The ability to sense environmental temperature as pleasant or unpleasant is associated with the activity of thermo‐sensitive neurons in the peripheral nervous system. Differential sensation of pleasant environmental temperatures (warm and cool) versus unpleasant and noxious (cold and hot) temperatures requires the definition of thresholds and ...
openaire   +2 more sources

Structural basis for intrinsic thermosensing by the master virulence regulator RovA of Yersinia [PDF]

open access: yes, 2012
Pathogens often rely on thermosensing to adjust virulence gene expression. In yersiniae, important virulence-associated traits are under the control of the master regulator RovA, which uses a built-in thermosensor to control its activity.
Mendonca, Chriselle   +6 more
core   +1 more source

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