Results 81 to 90 of about 33,156 (309)
Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair
Advanced Science, EarlyView.Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou +14 more
wiley +1 more source
Molecularly imprinted beads with double thermosensitive gates for selective recognition of proteins
, 2011 Molecularly imprinted beads with double thermosensitive gates for selective recognition of proteinsA new approach is reported on the use of poly(N-isopropylacrylamide) (PNIPAM)-coated molecularly imprinted beads (coated MIP beads) for controlling the ...
Yuan, Xia +6 more
core +1 more source
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Advanced Science, EarlyView.Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs
Molecules, 2015 Hydrogels are three-dimensional materials that can withstand a great amount of water incorporation while maintaining integrity. This allows hydrogels to be very unique biomedical materials, especially for drug delivery.
Matthew McKenzie +5 more
doaj +1 more source
, 2009 A thermosensitive macroporous hydrogel showing selectivity for the lysozyme was developed by an imprinting procedure that is based on metal coordinate interaction.
Zhang, Yu-Kui +10 more
core +1 more source
Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management
Advanced Science, EarlyView.A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao +9 more
wiley +1 more source
, 2016 Lu-Lu Wang, Shuai Huang, Hui-Hui Guo, Yan-Xing Han, Wen-Sheng Zheng, Jian-Dong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical
Huang S +5 more
core
, 1977 It is reported here that transfer by means of a conjugative process of an oncogenic plasmid from a virulent strain of Agrobactenum tumefaciens to a strain of that organism that had been cured of the plasmid is thermosensitive.
Tempé, Jacques +4 more
core +1 more source
Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism
Advanced Science, EarlyView.Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He +7 more
wiley +1 more source
Drug Delivery, 2018 Ganciclovir (GCV) is one of the most widely used antiviral drugs for the treatment of cytomegalovirus (CMV) retinitis. In this context, the aim of this study was to design in situ thermosensitive hydrogels for GCV ocular delivery by intravitreal ...
Qiyue Wang +4 more
doaj +1 more source