Results 191 to 200 of about 3,260,723 (286)

AI‐Revealed Transition From Density‐ to Connectivity‐Controlled Mechanics in Hierarchical Porous Materials

open access: yesSmall, EarlyView.
Using synchrotron‐based multiscale imaging, generative modeling algorithms, and computational mechanics models, our study reveals a scale‐dependent transition in bone mechanics. The results of the power‐scaling law illustrate a transition from density‐controlled stiffness at the trabecular scale to connectivity‐controlled, porosity‐sensitive mechanics ...
Milad Masrouri   +3 more
wiley   +1 more source

Unlocking Extra Flexibility of Soft Porous Crystals via Hydrogen Bonding Interaction for Multistep Acetylene Sorption

open access: yesSmall, EarlyView.
Minor ligand modification in a CID‐type flexible PCP induces a fivefold increase in acetylene uptake and > 270% pore expansion. By replacing isophthalate with pyridine‐3,5‐dicarboxylate, the framework exhibits hydrogen‐bond‐assisted multistep gate‐opening behavior and selective adsorption of acetylene over other C2 hydrocarbons.
Christophe Lavenn   +11 more
wiley   +1 more source

Think Beyond The Core: Computationally Decoding the Hydrophilic Corona of Drug‐Loaded Polymer Micelles

open access: yesSmall, EarlyView.
Drug‐loaded ABA‐type triblock copolymer micelles with a hydrophobic poly(2‐n‐butyl‐2‐oxazine) core (B‐block) and hydrophilic coronas (pEG, pDMAA, pSAR (A‐block)) are investigated by all‐atom molecular dynamics simulations at 20% and 60% curcumin loadings.
Maksym Karachevtsev   +5 more
wiley   +1 more source

Stoichiometric Binding of Cyclophilin‐A to The HIV‐1 Capsid Modulates Its Mechanoelastic Properties

open access: yesSmall, EarlyView.
The HIV‐1 capsid is a protein nanocapsule that must balance rigidity and flexibility to enter the cell nucleus. Atomic force microscopy simulations reveal that binding of the host protein Cyclophilin A tunes this mechanical response: partial coverage preserves deformability, while excessive binding induces brittleness and failure.
Juan S. Rey   +2 more
wiley   +1 more source

Impact of Pasteurization and Storage on the Microbiological Composition and Lipid Degradation of Human Milk Cream. [PDF]

open access: yesFoods
Escuder-Vieco D   +9 more
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

open access: yesSmart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang   +8 more
wiley   +1 more source

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