Results 1 to 10 of about 35 (27)

Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one, a Promising Inhibitor of DYRK1A [PDF]

Pharmaceuticals, 2019
International audienceDual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) hyperactivity has been linked to the development of a number of human malignancies.
Besson, Thierry, Bhansali, Rahul, Couly, Florence, Crispino, John D., Fruit, Corinne, Lindberg, Mattias F., Meijer, Laurent, Rammohan, Malini   +7 more
core   +7 more sources

Late-stage C-H Arylation of Thiazolo[5,4-f]quinazolin-9(8H)-one Backbone: Synthesis of an Array of Potential Kinase Inhibitors [PDF]

Synthesis, 2017
International ...
Besson, Thierry, Couly, Florence, Dubouilh-Benard, Carole, Fruit, Corinne, Laurent, Meijer   +4 more
core   +4 more sources

ChemInform Abstract: Pd-Catalyzed and Copper Assisted Regioselective Sequential C2 and C7 Arylation of Thiazolo[5,4-f]quinazolin-9(8H)-one with Aryl Halides.

ChemInform, 2016
AbstractThe synthetically useful title transformation is performed in a convenient one‐pot manner.
Harari
core   +2 more sources

Late-Stage C-H arylation of Thiazolo[5,4-f]quinazolin-9(8H)-one Backbone: Synthesis of an Array of Potential Kinase Inhibitors

, 2018
International ...
Fruit, Corinne
core   +3 more sources

Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases [PDF]

Molecules, 2016
A library of thirty novel thiazolo[5,4-f]quinazolin-9(8H)-one derivatives belonging to four series designated as 12, 13, 14 and 15 was efficiently prepared, helped by microwave-assisted technology when required. The efficient multistep synthesis of methyl 6-amino-2-cyano- benzo[d]thiazole-7-carboxylate (1) has been reinvestigated and performed on a ...
Hédou, Damien, Godeau, Julien, Loaëc, N., Meijer, L., Fruit, Corinne, Besson, Thierry   +5 more
openaire   +5 more sources

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. [PDF]

J Med Chem, 2020
Kang D, Ruiz FX, Feng D, Pilch A, Zhao T, Wei F, Wang Z, Sun Y, Fang Z, De Clercq E, Pannecouque C, Arnold E, Liu X, Zhan P.   +13 more
europepmc   +1 more source

Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. [PDF]

ACS Med Chem Lett, 2013
Guillon R, Pagniez F, Picot C, Hédou D, Tonnerre A, Chosson E, Duflos M, Besson T, Logé C, Le Pape P.   +9 more
europepmc   +1 more source

Pd-Catalyzed and Copper Assisted Regioselective Sequential C2 and C7 Arylation of Thiazolo[5,4-f]quinazolin-9(8H)-one with Aryl Halides

Organic Letters, 2016
A selective functionalization of thiazolo[5,4-f]quinazolin-9(8H)-one has been developed through sequential activation of C-H bonds to furnish diarylated compounds. This strategy allows the regioselective C2 and C7 arylation by a judicious choice of coupling partners and bases, requiring no additional ligands or directing groups. Differently substituted
Harari, Marine, Couly, Florence, Fruit, Corinne, Besson, Thierry   +3 more
openaire   +4 more sources

Pd-Catalyzed and copper -assisted sequential C2 and C7 arylation of potent bioactive thiazolo[5,4-f]quinazolin-9(8H)-ones

2016
openaire   +1 more source

Photo-/electrocatalytic functionalization of quinoxalin-2(1H)-ones

Chinese Journal of Catalysis, 2021
Kai Sun, Fang Xiao, Bing Yu
exaly