Results 111 to 120 of about 1,817,384 (272)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Shear thickening of highly viscous granular suspensions

, 2014
We experimentally investigate shear thickening in dense granular suspensions under oscillatory shear. Directly imaging the suspension-air interface, we observe dilation beyond a critical strain $\gamma_c$ and the end of shear thickening as the maximum ...
Brown, Eric, Jaeger, Heinrich M., Majumdar, Sayantan, Xu, Qin   +3 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Bedside diaphragmatic ultrasound as a predictor of high-flow nasal cannula outcome in patients with type II respiratory failure

The Egyptian Journal of Bronchology
Heated and humidified high-flow nasal cannula (HFNC) oxygen therapy is well recognized in the management of hypoxemic respiratory failure; however, its role in acute hypercapnic respiratory failure remains less well defined and requires further ...
Hadeel Abd El Wahab Mohamed, Hassan Mahmoud Amin, Mennat Allah Ahmed Anwar, Aml Ibrahim Bayoumi   +3 more
doaj   +1 more source

The non-monotonic shear-thinning flow of two strongly cohesive concentrated suspensions

, 2014
The behaviour in simple shear of two concentrated and strongly cohesive mineral suspensions showing highly non-monotonic flow curves is described. Two rheometric test modes were employed, controlled stress and controlled shear-rate.
Buscall, Richard, Kusuma, Tiara E., Rubasingha, Sayuri, Scales, Peter J., Stickland, Anthony D., Teo, Hui-En, Worrall, Graham L.   +6 more
core   +1 more source

Reduced white matter fractional anisotropy mediates cortical thickening in adults born preterm with very low birthweight

NeuroImage, 2019
Development of the cerebral cortex may be affected by aberrant white matter development. Preterm birth with very low birth weight (VLBW) has been associated with reduced fractional anisotropy of white matter and changes in cortical thickness and surface area.
Rimol, Lars Morten, Botellero, Violeta NL, Bjuland, Knut Jørgen, Løhaugen, Gro, Lydersen, Stian, Evensen, Kari Anne Indredavik, Brubakk, Ann-Mari, Eikenes, Live, Indredavik, Marit Sæbø, Martinussen, Marit, Yendiki, Anastasia, Håberg, Asta, Skranes, Jon Sverre   +12 more
openaire   +3 more sources

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Diaphragmatic ultrasound as a predictor for successful weaning from mechanical ventilation

Egyptian Journal of Chest Disease and Tuberculosis, 2019
Background Diaphragm ultrasound has lately been used in the prediction of successful weaning from mechanical ventilation. Aim To assess diaphragm thickening fraction (DTF) and mobility measured by ultrasound as predictors of successful weaning.
Ahmed G Elgazzar, Khaled M Kamel, Osama I Mohammad, Basma S Abd Elraoof   +3 more
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source