Results 61 to 70 of about 225,294 (263)

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Upper Lumbar Intradural Disc Herniation: A Rare Case Report and Etiologic Analysis

Journal of Pain Research, 2021
Jia Chen,1,2 Hai-Jian Ni,1,2 Fei Xue,3 Yun-Shan Fan,1,2 Xi-Fan Li,4 Xian-Zhen Chen,3 Shi-Sheng He1,2 1Department of Orthopaedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of ...
Chen J, Ni HJ, Xue F, Fan YS, Li XF, Chen XZ, He SS   +6 more
doaj  

The Lift Project: Your Limbo is Listening

, 2022
The Lift Project is an evidence-based mental health and wellbeing program that draws together the findings of over 400 studies from the disciplines of Neuroscience, Lifestyle Medicine and Positive Psychology.
Morton, Darren
core  

Comparative Evaluation of Chelator‐Conjugated Peptides for Lead‐Labeled SSTR2‐Targeted Theranostics: Integrated Computational Modeling and Preclinical Validation

Advanced Science, EarlyView.
The study integrates density functional theory with radiochemical and biological validation to compare DOTA‐, PSC‐, and DOTAM‐based chelator‐conjugates for 203Pb/212Pb theranostic applications. Distinct differences in metal coordination, electrostatic properties, conformational flexibility, cellular uptake, biodistribution, and dosimetry are identified
Jeongyun Kim, Na Yeon Han, Ayman Muzammal, Jae Hun Ahn, Changkeun Im, Sujin Kim, Sairan Eom, Choong Mo Kang, Ku Kang, Yong Jin Lee, Kyo Chul Lee, Michael K. Schultz, Dongyoul Lee   +12 more
wiley   +1 more source

Comparing the Electrical Activity of Selected Leg and Thigh Muscles during Performing Functional Movements in Female Athletes with and without Chronic Ankle Instability [PDF]

مجله دانشگاه علوم پزشکی گرگان
Background and Objective: Ankle instability is one of the most prevalent injuries among athletes. Biomechanical changes, sensory-motor impairments, and neuromuscular disorders have been reported in individuals with chronic ankle instability.
Fatemeh Akbari, Mohammad Rabiei, Banafshe Mohammadi, Sajad Bagherian   +3 more
doaj  

Dynamic analysis and optimization of snatch lift based on barbell trajectory and on an anthropometric model comprised of six links

Engineering Reports
Weightlifting requires explosive strength, high speed, and flexibility. The aim of this research is to present a method based on barbell trajectory and on an anthropometric model comprised of six links for dynamic analysis and optimization of snatch lift.
Min Hyok Jon, Un‐Ryong Rim
doaj   +1 more source

The Lift Project: Food Feeds Your Mood

, 2022
The Lift Project is an evidence-based mental health and wellbeing program that draws together the findings of over 400 studies from the disciplines of Neuroscience, Lifestyle Medicine and Positive Psychology.
Morton, Darren
core  

Biomimetic Nanoplatform for Fibrosis Remodeling and Anti‐PD‐1 Potentiation via Cu+/Ca2+ Ion Dysregulation and TGF‐β Inhibition in PDAC

Advanced Science, EarlyView.
A biomimetic nanoplatform (RPm@CC‐LY) remodels fibrotic stroma via sustained TGF‐β inhibition, triggers oxidative stress and apoptosis through Cu+‐mediated Fenton chemistry and Ca2+ overload, and reprograms macrophages and dendritic cells to boost CD8+ T cell infiltration.
Jianmei Li, Qinlong Wen, Jie Dai, Li Yang, Feng Xiong, Zhigong Wei, Xingchen Peng   +6 more
wiley   +1 more source

The Lift Project: Motion Creates Emotion

, 2022
The Lift Project is an evidence-based mental health and wellbeing program that draws together the findings of over 400 studies from the disciplines of Neuroscience, Lifestyle Medicine and Positive Psychology.
Morton, Darren
core  

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source