Results 71 to 80 of about 319,151 (294)

Peak soil: Is it a useful concept?

International Soil and Water Conservation Research
The concept of peak soil, the hypothetical point at which global soil productivity enters a sustained decline, has emerged as a metaphor for soil degradation.
Alex McBratney, Budiman Minasny, Amin Sharififar, Pasquale Borrelli, Sandra J. Evangelista, Julia Feeth, Damien Field, Nicolas Francos, Irene Heuser, Anilkumar Hunakunti, Daniel Irving, Thilini Jayasekara, Fatima Maria de Souza Moreira, Cristine L.S. Morgan, Wartini Ng, Julio C.Pachón Maldonado, Mercedes Román Dobarco, Quentin Styc, Mara Thiene, David Watt, Penelope Wensley, Liesl Wiese, Jae E. Yang   +22 more
doaj   +1 more source

Divergent Responses of Bacterial Communities to Permafrost Degradation and Their Associations With Carbon Across Vertical Profiles

Advanced Science, EarlyView.
Bacterial α‐diversity decreases, but stochasticity and community stability increase across the 15 m‐depth vertical profiles and along the degraded gradient within the active layer. The abundance and interaction of core taxa mainly control community stability in the active and permafrost layers, respectively.
Shengyun Chen, Yuzheng Gu, Ali Bahadur, Enyan Liu, Tonghua Wu, Xiaofan Zhu, Yuanqiang Zou, Hewei Liang, Peijie Wei, Linwei Wu, Qingbai Wu, Peizhi Yang, Hongyan Yu, Yunfeng Yang   +13 more
wiley   +1 more source

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source

ROBOTIC REPLICATION OF LIVING THINGS AND IMPLICATIONS FOR WARFARE

Margalla Papers
The paper discusses nature-inspired robotic replications, their potential military applications, implications for warfare, and the perspective of International Humanitarian Law (IHL). Historically, animals have been used in war, helping to turn the tide
Atta Ullah, Sher Ali Kakar
doaj  

Identifying factors for promoting evidence-based policymaking in Japan with the perspective of policymakers, researchers and knowledge brokers: a semistructured interview

Health Research Policy and Systems
Background The promotion of evidence-based policymaking (EBPM) is increasingly recognized globally for its potential to maximize health outcomes by efficiently utilizing finite resources and focusing on evidence.
Yuko Arimura, Yuko Yanagawa, Shota Kiuchi, Haruka Matsuyama, Hinata Uehata, Maiko Suto, Hisaya Tomori, Kenji Takehara, Sonoko Sensaki   +8 more
doaj   +1 more source

The think tanks roll [PDF]

BMJ, 1988
Sounds of protest from demonstrating nurses and health workers on their "day of action" penetrated the Commons committee room where the social services select committee was grappling sedately with the same issue. Each in its fashion is part of the democratic process, though it is arguable which has more impact on the government. But in a week that also
openaire   +2 more sources

Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis

Advanced Science, EarlyView.
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan   +6 more
wiley   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Real‐Time Digital Micromotor Tracking‐Enabled Ultrasensitive Immunoassay

Advanced Science, EarlyView.
An AI‐facilitated real‐time digital micromotor tracking‐enabled immunoassay is developed, which leverages a self‐developed multi‐microparticle tracking system to monitor micromotor motion trajectories in a real‐time manner for digital protein analysis.
Jingjing Shi, Zuhua Yu, Hui Tian, Wenjiao Fan, Yuanyuan Sun, Wei Ren, Chenghui Liu   +6 more
wiley   +1 more source