Results 1 to 10 of about 68,955 (108)

Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut

Nature Microbiology, 2023
Bile salt hydrolases encoded by the gut microbiome shape the bile acid pool, including microbial conjugated bile acids, which impact Clostridioides difficile infection in the murine gut.
M. H. Foley, Morgan E. Walker, A. Stewart, Sarah O’Flaherty, Emily C. Gentry, Shakshi Patel, Violet V. Beaty, Garrison B. Allen, Meichen Pan, J. B. Simpson, Caroline D. Perkins, Molly E. Vanhoy, Michael K. Dougherty, Sarah K. McGill, Ajay S. Gulati, P. Dorrestein, E. Baker, M. Redinbo, R. Barrangou, C. Theriot   +19 more
semanticscholar   +1 more source

Discovery and mechanism-guided engineering of BHET hydrolases for improved PET recycling and upcycling

Nature Communications, 2023
Although considerable research achievements have been made to address the plastic crisis using enzymes, their applications are limited due to incomplete degradation and low efficiency.
Anni Li, Yijie Sheng, Haiyang Cui, Minghui Wang, Luxuan Wu, Yibo Song, Rongrong Yang, Xiujuan Li, He Huang   +8 more
semanticscholar   +1 more source

An Overview into Polyethylene Terephthalate (PET) Hydrolases and Efforts in Tailoring Enzymes for Improved Plastic Degradation

International Journal of Molecular Sciences, 2022
Plastic or microplastic pollution is a global threat affecting ecosystems, with the current generation reaching as much as 400 metric tons per/year. Soil ecosystems comprising agricultural lands act as microplastics sinks, though the impact could be ...
Nurul Fatin Syamimi Khairul Anuar, F. Huyop, Ghani Ur-Rehman, Faizuan Abdullah, Yahaya M. Normi, M. K. Sabullah, Roswanira Abdul Wahab   +6 more
semanticscholar   +1 more source

The Role of Glycoside Hydrolases in Phytopathogenic Fungi and Oomycetes Virulence

International Journal of Molecular Sciences, 2021
Phytopathogenic fungi need to secrete different hydrolytic enzymes to break down complex polysaccharides in the plant cell wall in order to enter the host and develop the disease.
V. Rafiei, H. Vélëz, G. Tzelepis
semanticscholar   +1 more source

Hydrolases: The most Diverse Class of Enzymes

Hydrolases [Working Title], 2022
Being the largest and most diverse class of enzymes, hydrolases offer an opportunity to explore the conformational diversity which forms the basis of their differential biological functions. In recent times, there is an urge to re-evaluate and update our
E. Shukla, Ameya D. Bendre, Sushama M. Gaikwad   +2 more
semanticscholar   +1 more source

Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health

Microorganisms, 2021
The gut microbiota has been increasingly linked to metabolic health and disease over the last few decades. Several factors have been suggested to be involved in lipid metabolism and metabolic responses.
M. Bourgin, Aïcha Kriaa, Héla Mkaouar, Vincent Mariaule, Amin Jablaoui, E. Maguin, M. Rhimi   +6 more
semanticscholar   +1 more source

(ADP-ribosyl)hydrolases: structure, function, and biology

Genes & Development, 2020
In this review, Rack et al. provide an overview of the different families of (ADP- ribosyl)hydrolases and discuss their molecular functions, physiological roles, and influence on human health and disease.
J. Rack, L. Palazzo, I. Ahel
semanticscholar   +1 more source

Computational design of serine hydrolases.

Science
The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of RFdiffusion with an ensemble generation method for ...
Anna Lauko, S. Pellock, K. Sumida, Ivan Anishchenko, David Juergens, Woody Ahern, Jihun Jeung, Alex Shida, Andrew C Hunt, Indrek Kalvet, Christoffer H Norn, Ian R. Humphreys, C. Jamieson, Rohith Krishna, Yakov Kipnis, A. Kang, Evans Brackenbrough, Asim K. Bera, Banumathi Sankaran, K. N. Houk, David Baker   +20 more
semanticscholar   +2 more sources

The modular structure of α/β‐hydrolases

The FEBS Journal, 2020
The α/β‐hydrolase fold family is highly diverse in sequence, structure and biochemical function. To investigate the sequence–structure–function relationships, the Lipase Engineering Database (https://led.biocatnet.de) was updated.
Tabea L Bauer, Patrick C. F. Buchholz, J. Pleiss   +2 more
semanticscholar   +1 more source

Uncovering the activities, biological roles, and regulation of bacterial cell wall hydrolases and tailoring enzymes

Journal of Biological Chemistry, 2020
Bacteria account for 1000-fold more biomass than humans. They vary widely in shape and size. The morphological diversity of bacteria is due largely to the different peptidoglycan-based cell wall structures that encase bacterial cells.
T. Do, J. Page, S. Walker
semanticscholar   +1 more source