Results 1 to 10 of about 916 (80)
European Journal of Organic Chemistry, 2005 AbstractDynamic combinatorial thiolester libraries were efficiently generated from pools of thiols and acyl functionalities through reversible transthiolesterification in aqueous media at neutral pH. The dynamic features of the library generation were investigated, and the libraries were screened against acetylcholinesterase, clearly demonstrating the ...
Rikard Larsson, Olof Ramström
openaire +2 more sources
Stem Cells International, Volume 2019, Issue 1, 2019., 2019 Adipose‐derived mesenchymal stem cells (MSC‐ATs) are representative cell sources for cell therapy. However, how cell stress resulting from passage influences the MSC‐AT protein expression has been unclear. In this study, a protein expression analysis was performed by liquid chromatography with tandem mass spectrometry (LC‐MS/MS) using mouse primary ...
Yoshiki Nakashima +9 more
wiley +1 more source
The Role of the Selective Adaptor p62 and Ubiquitin‐Like Proteins in Autophagy
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 The ubiquitin‐proteasome system and autophagy were long viewed as independent, parallel degradation systems with no point of intersection. By now we know that these degradation pathways share certain substrates and regulatory molecules and show coordinated and compensatory function.
Mónika Lippai +2 more
wiley +1 more source
The BRCA1 ubiquitin ligase and homologous recombination repair
FEBS Letters, Volume 585, Issue 18, Page 2836-2844, September 16, 2011., 2011 Impairment of homologous recombination (HR), a vital process employed during repair of DNA double strand breaks and stalled DNA replication, provides a valuable opportunity for the cell to become transformed. Once transformed, the impairment turns to be a target for therapy as exemplified by the synthetic lethal strategy such as poly (ADP‐ribose ...
Tomohiko Ohta, Ko Sato, Wenwen Wu
wiley +1 more source
, 2016 Here we present the in vitro selection of a novel ribozyme specific for Zn2+-dependent catalysis on hydrolysis of a phosphorothiolate thiolester bond. The ribozyme, called the TW17 ribozyme, was evolved and selected from an artificial RNA pool covalently
Kun-Liang Lin (2129005) +8 more
core +1 more source
, 2015 Metallo-β-lactamases (MβLs) are bacterial Zn(II)-dependent hydrolases that confer broad-spectrum resistance to β-lactam antibiotics. These enzymes can be subdivided into three subclasses (B1, B2 and B3) that differ in their metal binding sites and their ...
Tierney D.L. +4 more
core +1 more source
Angewandte Chemie, Volume 137, Issue 21, May 19, 2025.Die Erzeugung funktionalisierter Ubiquitinbausteine mittels Expression in E. coli bietet Zugang zu verschiedenen Di‐, Tri‐ und Tetra‐Ubiquitinketten. Photoinitiierte Thiol‐En‐Klickreaktionen werden dabei in Kombination mit einer Maskierungs‐ und Schutzgruppenstrategie zum kontrollierten Aufbau von Ubiquitinketten sowie zur Semisynthese von ...
Moritz Urschbach +6 more
wiley +1 more source
Emergency Medicine International, Volume 2025, Issue 1, 2025.Background: Sepsis is a common and serious condition, where mitochondria and macrophage polarization play a crucial role. Therefore, this study aimed to identify and validate biomarkers for sepsis associated with mitochondria‐related genes (MCRGs) and macrophage polarization–related genes (MPRGs), providing new targets and strategies for therapeutic ...
Liping She +5 more
wiley +1 more source
Alzheimer's &Dementia, Volume 20, Issue S1, December 2024.Abstract Background DNA microarray‐based studies report differentially methylated positions (DMPs) in blood between cognitively unimpaired persons (CU) and persons with late‐onset dementia due to Alzheimer’s disease (AD) or Mild Cognitive Impairment (MCI) but interrogate less than 4% of the human genome.
Alexander E Boruch +12 more
wiley +1 more source
Reductive Release from a Hybrid PKS‐NRPS during the Biosynthesis of Pyrichalasin H
Chemistry – A European Journal, Volume 30, Issue 4, January 16, 2024.The reductive release of cytochalasin intermediates was studied in vitro, showing that the R‐domain requires a T‐domain tethered substrate, but has low selectivity for the amino acid and polyketide moieties. Direct 2‐electron reduction is the preferred mode of release, followed by rapid Knoevenagel cyclisation of the released aldehyde.
Henrike Heinemann +2 more
wiley +1 more source