Results 91 to 100 of about 68,955 (108)

Acyl-CoA thioesterase 8 induces gemcitabine resistance via regulation of lipid metabolism and antiferroptotic activity in pancreatic ductal adenocarcinoma. [PDF]

Acta Pharmacol Sin
Li BR, Wang T, Hu HF, Wu D, Zhou CJ, Ji SR, Zhuo QF, Li Z, Wang ZL, Fan GX, Jing DS, Yu CY, Qin Y, Chen XM, Xu JF, Xu XW.   +15 more
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Depalmitoylation and cell physiology: APT1 as a mediator of metabolic signals.

Am J Physiol Cell Physiol
Speck SL, Wei X, Semenkovich CF.
europepmc   +1 more source

GABA_AR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation. [PDF]

Transl Psychiatry
Tong J, Gao J, Qi Y, Gao Z, Wang Q, Liu Y, Yuan T, Ren M, Yang G, Li Z, Li J, Sun H, Zhao X, Leung YY, Mu Y, Xu J, Lu C, Peng S, Ge L.   +18 more
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USP11-PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA-cGAS-STING Pathway After Intracerebral Hemorrhage. [PDF]

Adv Sci (Weinh)
He J, Qin Z, Cai Y, Liu H, Wang T, Hu Q, Xu Y, Yang P, Wu X, Qu Y, Guo W.   +10 more
europepmc   +1 more source

Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor. [PDF]

J Proteome Res
O'Brien DP, Jones HBL, Shi Y, Guenther F, Vendrell I, Viner R, Brennan PE, Mead E, Zarganes-Tzitzikas T, Davis JB, Pinto-Fernández A, England KS, Murphy EJ, Turnbull AP, Kessler BM.   +14 more
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Functional dissection of the zDHHC palmitoyltransferase 5-golgin A7 palmitoylation complex. [PDF]

J Biol Chem
Kahlson MA, Ritho J, Gomes JV, Wang H, Butterwick JA, Dixon SJ.   +5 more
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USP11 promotes lipogenesis and tumorigenesis by regulating SREBF1 stability in hepatocellular carcinoma. [PDF]

Cell Commun Signal
Xu Y, Zeng J, Liu K, Li D, Huang S, Fu S, Ye M, Tao S, Wu J.   +8 more
europepmc   +1 more source

Nanobody-thioesterase chimeras to specifically target protein palmitoylation. [PDF]

Nat Commun
Kuo CW, Gök C, Fulton H, Dickson-Murray E, Adu S, Gallen EK, Mary S, Robertson AD, Jordan F, Dunning E, Mullen W, Smith GL, Fuller W.   +12 more
europepmc   +1 more source

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A promiscuous glutathione transferase transformed into a selective thiolester hydrolase

Org. Biomol. Chem., 2006
Human glutathione transferase A1-1 (hGST A1-1) can be reengineered by rational design into a catalyst for thiolester hydrolysis with a catalytic proficiency of 1.4 x 10(7) M(-1). The thiolester hydrolase, A216H that was obtained by the introduction of a single histidine residue at position 216 catalyzed the hydrolysis of a substrate termed GSB, a ...
Sofia, Hederos, Lotta, Tegler, Jonas, Carlsson, Bengt, Persson, Johan, Viljanen, Kerstin S, Broo   +5 more
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Dynamic Combinatorial Thiolester Libraries for EfficientCatalytic Self‐Screening of Hydrolase Substrates

European Journal of Organic Chemistry, 2005
AbstractDynamic combinatorial thiolester libraries were efficiently generated from pools of thiols and acyl functionalities through reversible transthiolesterification in aqueous media at neutral pH. The dynamic features of the library generation were investigated, and the libraries were screened against acetylcholinesterase, clearly demonstrating the ...
Rikard Larsson, Olof Ramström
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