Results 151 to 160 of about 2,737 (218)

Gut-specific Neprilysin Deletion Protects Against Fat-induced Insulin Secretory Dysfunction in Male Mice.

Endocrinology
Esser N, Mongovin SM, Barrow BM, Zraika S.   +3 more
europepmc   +1 more source

Polarization Controlled Assembly of Ultrathin Thiorphan Nanostructures on ZnO Surface Facets.

Langmuir, 2023
Despite the importance of thiorphan as a small molecule with vital biological roles, its interactions with zinc oxide (ZnO) nanomaterials that are prospective in drug delivery and theranostic applications have not yet been sufficiently explored. Here the
E. Ukraintsev, H. Hematian, B. Rezek
semanticscholar   +4 more sources

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Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin.

Biochemistry, 1989
The three-dimensional structures of (S)-thiorphan and (R)-retro-thiorphan bound to thermolysin have been determined crystallographically and refined to residuals of 0.183 and 0.187 at 1.7-A resolution. Thiorphan [N-[(S)-2-(mercaptomethyl)-1-oxo-3-phenylpropyl]glycine] [HSCH2CH(CH2C6H5)CONHC-H2COOH] and retro-thiorphan [[[(R)-1-(mercaptomethyl)-2 ...
S. Roderick, M. Fournie-Zaluski, B. Roques, B. Matthews   +3 more
semanticscholar   +4 more sources

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

Nature, 1980
There is both theoretical and therapeutic interest in establishing whether the signals conveyed by the enkephalins are turned off under the action of a specific peptidase which might, in this case, represent a target for a new class of psychoactive agents.
B. Roques, M. Fournie-Zaluski, E. Soroca, J. Lecomte, Bernard Malfroy, C. Llorens, Jean-Charles Schwartz   +6 more
semanticscholar   +3 more sources

Angiotensin receptor–neprilysin inhibitor (thiorphan/irbesartan) improved cardiac function in a rat model of myocardial ischemic reperfusion injury

Fundamental & Clinical Pharmacology, 2022
Mitochondria‐mediated apoptosis plays a critical role in myocardial ischemia reperfusion (IR) injury and causes a negative impact on cardiac efficiency and function.
Takwa Mohammed Abdulsalam, A. Hasanin, R. H. Mohamed, Eman Y Khairy, Dalia Mahmoud, Eman K. Habib, A. Badawy   +6 more
semanticscholar   +2 more sources

Asymmetric synthesis of the enkephalinase inhibitor thiorphan

The Journal of Organic Chemistry, 1985
Synthese de la N-[mercaptomethyl-2 phenyl-3 propionyl] glycine(thiorphane) a partir d'oxazolidones-2 ...
D. A. Evans, D. Mathre, W. L. Scott
semanticscholar   +2 more sources

Thiorphan potentiation of stress-induced analgesia in the mouse.

Life Sciences, 1982
Experiments were done to examine the analgesic effect of thiorphan alone or in combination with stress in mice. Analgesia was assessed by measuring jump latencies from a 55 degrees C hot plate. Thiorphan exhibited weak analgesic properties evidenced by significant increases in jump latencies only after 300 mg/kg i.p. Additional experiments were done to
R. Greenberg, E. O'Keefe
semanticscholar   +3 more sources

Determination of thiorphan, a racecadotril metabolite, in human plasma by LC-MS/MS and its application to a bioequivalence study in Chinese subjects
.

International journal of clinical pharmacology and therapeutics, 2020
OBJECTIVE The objective of this study was to use LC-MS/MS to compare the pharmacodynamic properties and bioequivalence of two 200-mg formulations of racecadotril: suspension formulation (test) and granule formulation (reference) in healthy Chinese ...
Lan Li, Chenlin Shen, Lian Tang, Yanxia Yu, Qin Zhou, Xiaohui Huang, Sudong Xue   +6 more
semanticscholar   +2 more sources

Study of thiorphan degradation

International Journal of Pharmaceutics, 1988
Abstract The degradation of the enkephalinase inhibitor thiorphan was studied. Liquid chromatography UV and electrochemical detections and several techniques of spectrometry showed that the degradation was oxidative and generates diastereoisomers of the corresponding disulfide.
F. Giménez, E. Postaire, P Prognon, M.D. Le Hoang, J Lecomte, D. Pradeau, G. Hazebroucq   +6 more
openalex   +2 more sources

Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2,Met5] enkephalin.

European Journal of Pharmacology, 1982
The intrathecal administration of thiorphan (dl-3-mercapto-2-benzylpropranoyl-glycine) had no effect in doses up to 70 microgram on the rat hot plate and tail flick. Administrations of these doses of thiorphan concurrently or up to 1 h prior to the intrathecal administration of [D-Ala2, Met5] enkephalin resulted in a dose dependent, leftward shift in ...
T. Yaksh, G. Harty
semanticscholar   +3 more sources