Results 201 to 210 of about 360,358 (247)

Debates over orphan drug pricing: a meta-narrative literature review. [PDF]

Orphanet J Rare Dis
Hanchard MS.
europepmc   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Transgender and gender nonconforming people's vulnerability to food insecurity: systematic review and meta-synthesis. [PDF]

Cad Saude Publica
Nascimento IMR, Reis APD, Andrade RTS, Pereira M.   +3 more
europepmc   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Call for collaboration: Drafting a concept inventory for assessing neuroscience courses and curriculum. [PDF]

J Undergrad Neurosci Educ
Gaudier-Diaz MM, Mitchell ME, Parekh SV, Robertson SD.   +3 more
europepmc   +1 more source

Label‐Free and Immobilization‐Free Protein‐Binding Assays by Ultraviolet Transient Absorption Microscopy

Advanced Science, EarlyView.
A femtosecond UV pump–probe microscope resolves binding‐induced changes in protein excited‐state dynamics and converts these intrinsic contrasts into an equilibrium affinity readout. By probing tryptophan responses directly in solution, the approach enables quantitative determination of dissociation constants without labeling or immobilization ...
Jianghao Shen, Qiangqiang Wang, Fan Wu, Yang Gao, Lu Lan, Pu Wang   +5 more
wiley   +1 more source

Near-infrared hyperspectral imaging combined with elemental and isotopic analyses reflects geographical origins of cultured salmonids. [PDF]

Curr Res Food Sci
Sun D, Li L, Han C, Zhou C, Li C, Ye H.
europepmc   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Access to essential medicines for noncommunicable diseases during conflicts: The case cardiovascular diseases, diabetes and epilepsy in Northern Syria. [PDF]

PLOS Glob Public Health
Aljadeeah S, Tarrafeta B, Fahed S, Kielmann K, Ravinetto R.   +4 more
europepmc   +1 more source

Research on enterprise network public opinion guiding decision-making considering crisis differentiation. [PDF]

PLoS One
Wang J, Li Y, Guo X, Chen H.
europepmc   +1 more source