Results 51 to 60 of about 1,849,360 (286)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Second-order Stable Finite Difference Schemes for the Time-fractional Diffusion-wave Equation

, 2014
We propose two stable and one conditionally stable finite difference schemes of second-order in both time and space for the time-fractional diffusion-wave equation.
Zeng, Fanhai
core   +2 more sources

From a Mechanical Lagrangian to the Schr\"odinger Equation. A Modified Version of the Quantum Newton's Law [PDF]

, 2002
In the one-dimensional stationary case, we construct a mechanical Lagrangian describing the quantum motion of a non-relativistic spinless system.
A. Bouda, Bouda A., Faraggi A. E., Floyd E. R., Landau L., Messiah A.   +5 more
core   +2 more sources

Quasi‐adjoint third order difference equations: oscillatory and asymptotic behavior [PDF]

International Journal of Mathematics and Mathematical Sciences, 1986
In this paper, asymptotic properties of solutions of urn:x-wiley:01611712:media:ijmm806976:ijmm806976-math-0001 are investigated via the quasi‐adjoint equation urn:x-wiley:01611712:media:ijmm806976:ijmm806976-math-0002 A necessary and sufficient condition for the existence of oscillatory solutions of (E+) is given.
openaire   +5 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Numerical Investigation of the Steady State of a Driven Thin Film Equation

Journal of Applied Mathematics, 2013
A third-order ordinary differential equation with application in the flow of a thin liquid film is considered. The boundary conditions come from Tanner's problem for the surface tension driven flow of a thin film.
A. J. Hutchinson, C. Harley, E. Momoniat
doaj   +1 more source

Global asymptotic properties of third-order difference equations

Computers & Mathematics with Applications, 2004
The nonoscillatory solutions of \(\Delta(p_n\Delta(r_n\Delta x_n))+ q_n f(x_{n+p})= 0\), \(p\in \{0,1,2\}\), are classified under suitable conditions. In the case \(p= 1\) their generalized zeros and asymptotic properties are described by means of an energy function.
Došlá, Z., Kobza, A.
openaire   +2 more sources