Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira +8 more
wiley +1 more source
Case Report: Pharmacogenetically-triggered fatal serotonin syndrome following sequential serotonergic therapy in Parkinson's disease: a case highlighting the role of <i>CYP2D6*10/*10</i> genotype and multifactorial drug interactions. [PDF]
Liu DY, Yi YH, Li N, Luo FM, Gong WJ.
europepmc +1 more source
A porous parylene‐coated electrode loaded with dexamethasone was developed to reduce inflammation after cochlear implantation. In guinea pigs, the device provided sustained drug release, maintained biocompatibility, improved auditory brainstem response thresholds, and reduced inflammatory cell infiltration and TNF‐α expression.
Chi‐Chieh Chang +11 more
wiley +1 more source
How does dung burial by coprophagous beetles modify the emergence of infectious strongyle nematode larvae? An experimental test across different soil depths. [PDF]
Mbundi MM +4 more
europepmc +1 more source
Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans +7 more
wiley +1 more source
Life Kinetics Training as a Multimodal Neurocognitive Intervention: Enhances Cognitive and Motor Performance in Badminton Athletes. [PDF]
Senja QS, Shan W, Ma X, Yi Q, Yan H.
europepmc +1 more source
Advances in cell sources, bioengineering, and manufacturing are reshaping the design of skin substitutes. This review highlights emerging strategies driving skin tissue engineering and discusses their potential to enable safer, reproducible, and clinically accessible skin substitutes for regenerative medicine.
Gilles Lemaître +7 more
wiley +1 more source
The value of retinal microvascular features in predicting risk stratification and long-term prognosis of patients with acute coronary syndrome. [PDF]
Chen Y, Chen L, Li H, Yu Z.
europepmc +1 more source
Electronic measurement of frequency and duration of close nurse-patient contacts during patient care in intensive and intermediate care units: a cross-sectional observational study. [PDF]
Neuwirth MM +4 more
europepmc +1 more source

