Results 51 to 60 of about 1,365,137 (306)
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Animal, 2021 The phytol moiety in chlorophyll molecules acts as an agonist of peroxisome proliferator-activated receptor-α in monogastric animals. The current study aimed to clarify the effects of dietary supplementation with phytol on the plasma concentrations of ...
L.L. Ding +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Middle Kingdom tombs of Asasif: archaeological fieldwork in 2017 [PDF]
Polish Archaeology in the Mediterranean, 2018 The recent works in the 2017 season at the North Asasif Necropolis have led to the discovery of Middle Kingdom burial assemblages, as well as funerary equipment dated to the Third Intermediate Period.
Patryk Chudzik
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ArtsThrough the coffin set of Tanethereret—dated to the first half of the 21st Dynasty—this article aims to underline the importance of analysing the masks and human features of ancient Egyptian yellow coffins and their value in disclosing new and important ...
Stefania Mainieri
doaj +1 more source
More items of funerary linen from the Deir el-Bahari burialassemblages [PDF]
Polish Archaeology in the Mediterranean, 2016 A corpus of funerary linen was found in the 2012/2013 season in one of the rock tombscut in the cliff bordering the Tuthmosis III temple platform in Deir el-Bahari during the work ofthe Polish–Egyptian Archaeological and Conservation Mission of the ...
Aleksandra Hallmann
doaj +1 more source
Monetary policy, COVID-19 immunization, and risk in the US stock markets
Cogent Economics & Finance, 2022 We examine how monetary policy of the Federal Reserve System, COVID-19 mortality cases, and vaccinations are associated with the US stock market volatility during the pandemic period.
Seungho Baek, Kwan Yong Lee
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source