Results 161 to 170 of about 4,067,400 (280)

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Untrustworthy sources on Facebook and Instagram in 2020: Concentrated exposure but no attitudinal effects. [PDF]

Sci Adv
Bergeron-Boutin O, Nyhan B, Settle J, Thorson E, Wojcieszak M, Brown T, Crespo-Tenorio A, Velasco Rivera C, Allcott H, Barberá P, Dimmery D, Freelon D, Gentzkow M, González-Bailón S, Guess AM, Kennedy E, Kim YM, Lazer D, Malhotra N, Moehler D, Pan J, Thomas DR, Tromble R, Wilkins A, Xiong B, Kiewiet de Jonge C, Franco A, Mason W, Stroud NJ, Tucker JA.   +29 more
europepmc   +1 more source

The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D2 receptor occupancy in humans

British Journal of Clinical Pharmacology, EarlyView.
Aim Clozapine, used for treatment‐resistant schizophrenia, has a narrow therapeutic window and highly variable plasma pharmacokinetics (PK), necessitating careful monitoring. Direct measurement of unbound brain PK in humans is unethical. To develop a physiologically based pharmacokinetic–pharmacodynamic (PBPK‐PD) model to predict clozapine brain ...
Mengxu Zhang, Thomas I. F. H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange   +3 more
wiley   +1 more source

Economic evaluations of antiobesity medications: A systematic literature review

British Journal of Clinical Pharmacology, EarlyView.
The global prevalence of obesity is rising rapidly. With several antiobesity medications approved and many more in development, understanding their economic value is increasingly important. This study reviews full economic evaluations of approved antiobesity medications to assess cost‐effectiveness and inform reimbursement and access decisions.
Martina Jurković, Almir Fajkić, Andrea Katrin Faour, Mirna Momčilović, Petra Turčić, Andrej Belančić   +5 more
wiley   +1 more source

Help-seeking and barriers to emergency care during out-of-hospital cardiac arrests in public housing areas: a qualitative study. [PDF]

BMJ Open
Juul Grabmayr A, Kragh AMR, Kjærholm S, Sheikh AP, Østergaard D, Hassager C, Folke F, Tjørnhøj-Thomsen T, Malta Hansen C.   +8 more
europepmc   +1 more source

String Figuring young children's perspectives of quality in English early childhood education and care

British Educational Research Journal, EarlyView.
Abstract Quality in early childhood education and care (ECEC) is a contested concept and has generally been conceptualised by inter‐related indicators such as staff qualifications, educational environment, policy or child‐to‐staff ratios. There has been a more limited emphasis on how young children might perceive and experience quality.
Nikki Fairchild, Éva Mikuska
wiley   +1 more source

Financing fragility and pandemic preparedness in Central Asia: a policy review of aid volatility, donor dynamics, and health system resilience. [PDF]

Front Public Health
Rakhimov B, Choi JW, Kim KH.
europepmc   +1 more source

Reception Baseline Assessment and ‘small acts’ of micro‐resistance

British Educational Research Journal, EarlyView.
Abstract In September 2021, following the global COVID‐19 pandemic, the Department for Education introduced a national standardised digital Reception Baseline Assessment (RBA) for all English 4‐year‐old children. We analyse RBA and its associated Quality Monitoring Visits, as a further intensification of the new public management of early years ...
Guy Roberts‐Holmes, Diana Sousa, Siew Fung Lee   +2 more
wiley   +1 more source

Tuberculous Cervicitis Mimicking Cervical Malignancy: A Diagnostic Challenge. [PDF]

Int J Womens Health
Zulfa F, Tjahyadi D, Djuwantono FW, Abdullah AR, Suardi A, Dewi OM.   +5 more
europepmc   +1 more source

Good governance of third party funding

, 2014
Third party funding of international litigation and arbitration is controversial. As a phenomenon that presents issues distinct from other forms of litigation funding, some principles for good governance need to be developed.
openaire   +2 more sources