Results 31 to 40 of about 8,252,977 (297)

Temporal lobe epilepsy and surgery selectively alter the dorsal, not the ventral, default-mode network

open access: yesFrontiers in Neurology, 2014
The default-mode network (DMN) is a major resting-state network. It can be divided in 2 distinct networks: one is composed of dorsal and anterior regions (referred to as the dorsal DMN, dDMN), while the other involves the more posterior regions (referred
Gaelle Eve Doucet   +6 more
doaj   +1 more source

Semi-stable subcategories for Euclidean quivers [PDF]

open access: yes, 2015
In this paper, we study the semi-stable subcategories of the category of representations of a Euclidean quiver, and the possible intersections of these subcategories.
Ingalls, Colin   +2 more
core   +3 more sources

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego   +10 more
wiley   +1 more source

Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers

open access: yesFrontiers in Endocrinology, 2016
The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias and hepatocellular carcinomas. Several laboratories, including ours, have also
Ryuta Tanimoto   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Promoting Environments that Measure Outcomes: Partnerships for Change

open access: yesJournal of Occupational Therapy Education, 2017
This paper describes the development of the PrEMO© (Promoting Environments that Measure Outcomes) program. PrEMO© is an innovative model promoting evidence-based practice (EBP) while developing capacity and quality of Level II fieldwork placements.
Roseann C. Schaaf   +5 more
doaj   +1 more source

Single-cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks involved In the Central Circadian Clock

open access: yesFrontiers in Neuroscience, 2016
Single-cell heterogeneity confounds efforts to understand how a population of cells organizes into cellular networks that underlie tissue-level function. This complexity is prominent in the mammalian suprachiasmatic nucleus (SCN).
James Park   +10 more
doaj   +1 more source

Descriptions of four new species of Cryptolestes Ganglbauer : with a revised key to the New World species and notes on other species (Coleoptera: Laemophloeidae) [PDF]

open access: yes, 2002
The following new species of Cryptolestes Ganglbauer are described and illustrated: Cryptolestes obesus Thomas, new species, Brazil; Cryptolestes turnbowi Thomas, new species, Honduras and Mexico; Cryptolestes inyoensis Thomas, new species, California ...
Thomas, Michael C.
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

From m-clusters to m-noncrossing partitions via exceptional sequences [PDF]

open access: yes, 2011
Let W be a finite crystallographic reflection group. The generalized Catalan number of W coincides both with the number of clusters in the cluster algebra associated to W, and with the number of noncrossing partitions for W.
Buan, Aslak Bakke   +2 more
core   +3 more sources

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