Results 61 to 70 of about 8,252,977 (297)

De vuelta a Hobbes

Estudios Políticos, 2013
El propósito de este artículo es mostrar que el Estado constituye la forma más idónea para resolver las amenazas de inseguridad y guerra que acosan las sociedades contemporáneas. Para sustentar este planteamiento, en el artículo se rescatan varios de los
Wilmar Martínez Márquez
doaj  

Implementing a clinical scientist-led screening clinic for hypertrophic and dilated cardiomyopathies

Echo Research and Practice
Background The burden of screening for inherited cardiac conditions on health services grows ever larger, with each new diagnosis necessitating screening of additional family members.
Jane Draper, Rachel Bastiaenen, Gerald Carr-White, Teofila Bueser, Jessica Webb, Colin Evans, Soraya Nuthoo, Nabeel Sheikh   +7 more
doaj   +1 more source

Capture Cavities For The Cw Polarized Positron Source Ce+baf [PDF]

EPJ Web of Conferences
The initial design of the capture cavities for the continuous wave (CW) polarized positron beams at Jefferson Lab (Ce+BAF) is presented. A chain of standing wave multi-cell copper cavities inside a solenoid tunnel are selected to improve the positron ...
Wang Shaoheng, Ushakov Andriy, Grames Joseph, Raut Nabin, Rimmer Robert, Roblin Yves, Wang Haipeng   +6 more
doaj   +1 more source

Postprint Copy of Years of Teaching Dangerously: Interfacing Thomas Cromwell in Canon and Fandom, Michael Drayton, “W.S.,” and Hilary Mantel [PDF]

, 2016
When Sir Thomas Bodley founded the Bodleian Library, he sought to keep “baggage books,” “riff-raff books,” and distasteful literature off the shelves. The question of keeping literature in or out of a library or canon is never simply about literature; it
Laurie Ringer
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Structural implications for selective targeting of PARPs

Frontiers in Oncology, 2013
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that use NAD+ as a substrate to synthesize polymers of ADP-ribose (PAR) as post-translational modifications of proteins.
Jamin D. Steffen, Jonathan R. Brody, Roger S. Armen, John Matteson Pascal   +3 more
doaj   +1 more source

Thomas-Fermi approximation to static vortex states in superfluid trapped atomic gases

, 2003
We revise the Thomas-Fermi approximation for describing vortex states in Bose condensates of magnetically trapped atoms. Our approach is based on considering the hbar -> 0 limit rather than the N -> infinity limit as Thomas-Fermi approximation in close ...
Schuck, P., Urban, M., Vinas, X.
core   +3 more sources

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source