Experimental Physiology, EarlyView.Abstract Microgravity is associated with stature increases, back pain and post‐flight intervertebral disc (IVD) herniation. This study aims to determine whether 30 s seated 50% body weight (BW) axial loading is comparable to 15 min sitting upright in 1 g upon changes in stature, anterior lumbar IVD height (via ultrasound), passive vertebral stiffness ...
David Marcos‐Lorenzo +6 more
wiley +1 more source
Exploring thoracic aorta ECM alterations in Marfan syndrome: insights into aorta wall structure. [PDF]
Sci Repde Souza RB +15 more
europepmc +1 more source
Experimental Physiology, EarlyView.Abstract Central arterial stiffening, particularly of the proximal aorta, is increasingly recognised as a pivotal contributor to cardiovascular disease, dementia, and mild cognitive impairment. Loss of Windkessel function amplifies pulsatile pressure, reduces diastolic perfusion and accelerates microvascular damage in the brain.
Jun Sugawara, Hirofumi Tanaka
wiley +1 more source
Credibility Assessment of the Patient-Specific Modeling of the Aneurysmal Ascending Thoracic Aorta: Verification, Validation and Uncertainty Quantification. [PDF]
Cardiovasc Eng TechnolScuoppo R +3 more
europepmc +1 more source
Computational analysis to assess hemodynamic forces in descending thoracic aortic aneurysms
The Journal of Physiology, EarlyView.Abstract figure legend Left: Pre‐processing. First, we perform the segmentation of the Computer Tomography angiorgraphy (angio‐CT) scans of a healthy patient, obtaining the surface of a healthy thoracic aorta with a Type III aortic arch. Then, we build nine ideal configurations with Descending Thoracic Aortic Aneurysm (DTAA), varying the aortic arch ...
Francesca Duca +7 more
wiley +1 more source
Thoracic endovascular aortic repair for traumatic and non-traumatic rupture of the descending thoracic aorta: A 15-year single-centre experience. [PDF]
Int J Cardiol Heart VascBerkenheide R +10 more
europepmc +1 more source
TMEM16A channel signalling microdomains in the regulation of vascular function
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley +1 more source
Combined aerobic and resistance exercise training restores perivascular adipose tissue function in the thoracic aorta of rats with heart failure. [PDF]
Clin Sci (Lond)Fontes MT +6 more
europepmc +1 more source
Acute intermittent hypercapnic hypoxia augments left ventricular contractility
The Journal of Physiology, EarlyView.Abstract figure legend Twenty‐four healthy adults were studied to determine the effects of an acute session of 40 min of intermittent hypercapnic hypoxia on cardiac performance. Cardiac function was assessed via echocardiography at rest and during graded stages of lower‐body negative pressure before and after the intervention to quantify load ...
Scott F. Thrall +8 more
wiley +1 more source