Results 41 to 50 of about 601,640 (261)

Thoracic Aortic Aneurysm and Factors Affecting Aortic Dissection [PDF]

Journal of Personalized Medicine, 2020
This study is aimed at investigating the relationship between inflammation, the number of vasa vasorum, and the presence of lipoprotein (a) [Lp(a)] in the aortic aneurysm wall, as well as the relationships of these pathological processes with the development of aneurysm wall dissection.
Petr V. Chumachenko, Anton Yu. Postnov, Alexandra G. Ivanova, Olga I. Afanasieva, Maksim A. Afanasiev, Mariam Bagheri Ekta, Vasily N. Sukhorukov, Grigoriy I. Kheimets, Igor A. Sobenin   +8 more
openaire   +2 more sources

Acute type B aortic dissection in the absence of aortic dilatation

, 2012
BackgroundIncreasing aortic diameter is thought to be an important risk factor for acute type B aortic dissection (ABAD). However, some patients develop ABAD in the absence of aortic dilatation. In this report, we sought to characterize ABAD patients who
J. B. Froehlich, Iternational Registry of Acute Aortic Dissection investigators, B. E. Muhs, F. L. Moll, K. A. Eagle, G. R. Upchurch, H. J. Patel, V. Rampoldi, S. Trimarchi, F. H. W. Jonker   +9 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Ascending thoracic aorta dimension and outcomes in acute type B dissection (from the International Registry of Acute Aortic Dissection [IRAD])

, 2011
It is not well known if the size of the ascending thoracic aorta at presentation predicts features of presentation, management, and outcomes in patients with acute type B aortic dissection.
J. B. Froehlich, Froehlich, James B, V. S. Ramanath, Ramanath, Vijay S, C. A. Nienaber, James B. Froehlich, Santi Trimarchi, O'Gara, Patrick T, Booher, Anna M, Harris, Kevin M, Reed E. Pyeritz, International Registry of Acute Aortic Dissection (IRAD) Investi,, Anna M. Booher, J. V. Cooper, Sundt, Thoralf M, Januzzi, James L, Eric M. Isselbacher, Nienaber, Christoph A, T. M. Sundt III, Christoph A. Nienaber, James L. Januzzi, Thoralf M. Sundt, Cooper, Jeanna V, S. Demertzis, Demertzis, Stefanos, Trimarchi, Santi, Jeanna V. Cooper, Vijay S. Ramanath, K. M. Harris, Kim A. Eagle, R. E. Pyeritz, K. A. Eagle, Patrick T. O'Gara, Pyeritz, Reed E, J. L. Januzzi, Eagle, Kim A, E. M. Isselbacher, P. T. O'Gara, S. Trimarchi, Kevin M. Harris, A. M. Booher, Stefanos Demertzis, Isselbacher, Eric M, O'Gara, Patrick T, International Registry of Acute Aortic Dissection (IRAD) Investi   +44 more
core   +1 more source

Late thoracic endovascular stent graft repair after complicated acute type B dissection [PDF]

, 2016
Thoracic endovascular stent repair is a life-saving treatment option for patients with complicated type B aortic dissection. In this article, we present a 32-yearold male case referred with ruptured acute type B aortic dissection after injury.
Odabasi, Dolunay, Kunt, Aysegul, Ozcan, Sedat, Odabaşı, Dolunay   +3 more
core   +1 more source

Type B aortic dissection in Loeys-Dietz syndrome and suspected heritable aortopathy: pregnancy, malperfusion, and whole-aorta repair in a three-patient case series

Annals of Vascular Surgery - Brief Reports and Innovations
Loeys-Dietz syndrome is an autosomal dominant connective tissue disorder within the spectrum of syndromic heritable thoracic aortic disease. We report three young women with Stanford type B aortic dissection in the setting of confirmed Loeys-Dietz ...
Edouard Dekkers, Giorgia Romano, Charles Swaelens   +2 more
doaj   +1 more source

Imaging characteristics and treatment strategies of traumatic diaphragmatic hernia with aortic dissection: a report of 3 cases

Journal of Cardiothoracic Surgery, 2023
Background Traumatic aortic dissection with traumatic diaphragmatic hernia is a rare traumatic disease. The purpose of this article is to investigate the imaging characteristics and treatment strategies for traumatic diaphragmatic hernia with aortic ...
Hao-Hao Wu, Shao-Song Tu, Fang-Biao Zhang   +2 more
doaj   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

A narrative review exploring the association between hypothyroidism and thoracic aortic diseases

JVS-Vascular Insights
Background: Thoracic aortic aneurysms (TAA) and aortic dissections (AD) are recognized as one of the leading causes of death in developed countries. Although mortality decreases if at-risk individuals are diagnosed early, on thorough screening, many fail
Mohammad Hamzah, BS, Fatima Al-Maaz, BS, Ahmad Chalhoub, BS, Rita Nemr, MD   +3 more
doaj   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source