Results 101 to 110 of about 135,530 (257)

Thoracic SMARCA4-deficient undifferentiated tumour – a case of an aggressive neoplasm

Polish Journal of Pathology
SMARCA4-deficient undifferentiated tumours exhibit undifferentiated and rhabdoid features. These highly aggressive neoplasms pose significant diagnostic challenges.
Gizem Teoman
doaj   +1 more source

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

Left Main Bronchus Root Prolongation to Cure 3 Patients whose Carina is Involved by Lung Cancer

Chinese Journal of Lung Cancer, 2011
Background and objective Patient whose carina is involved by carcinoma is difficult to treat by surgery. The aim of this study is to evaluate the safety and effectiveness of left main bronchus root prolongation to cure these patients.
Yangkai LI, Chengcheng XU, Wei SUN, Ni ZHANG, Xiangning FU   +4 more
doaj  

SMARCA4‐Deficient Undifferentiated Thoracic Tumor: Clinical Features and Prognosis of a Case Series and Literature Review

The Clinical Respiratory Journal
Introduction Thoracic SMARCA4‐deficient undifferentiated tumors (SMARCA4‐UT) are rare and aggressive epithelioid neoplasms characterized by the loss of the SMARCA4 gene.
Fangzhen Shan, Shuntao Liang, Youwen Zhang, Wei Wu, Guangxia Yang, Mei Yan, Xuemei Zhang, Yumao Miao, Linlin Liu, Jingjing Cai, Zhitao Shi, Bangdong Liu, Nannan Zhang   +12 more
doaj   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

IMPORTANCE OF IMMUNOHISTOCHEMISTRY IN THE DIFFERENTIAL DIAGNOSIS OF THORACIC NEOPLASMS

Introduction: Thoracic neoplasms present a significant diagnostic challenge due to the anatomical complexity of the thorax and the morphological overlap between pulmonary, pleural, mediastinal, and metastatic tumors. Although imaging techniques allow for adequate localization of lesions, their ability to establish tumor type is limited. In this context,
Marcel Leonardo Quintero Contreras, Anna Isabella Rojas Atencia, José Alexander Rubiano Pedroza   +2 more
openaire   +1 more source

Surgical Expert Consensus on Clinical Management of Advanced Thymoma and Thymic Carcinoma: A Beijing–Tianjin–Hebei Collaborative Initiative

Thoracic Cancer
Thymomas and thymic carcinomas represent rare epithelial‐derived thoracic neoplasms that, despite their low incidence, pose significant clinical challenges and impact patient survival.
Zhen Yu, Peng Zhang, Guoyan Qi, Deruo Liu, Tao Yu, YunFeng Zhang, Ji Ke, Xingguo Yang, Baoxun Zhang, Xintao Yu, Jian Cui, Xiang Gao, Lei Yu   +12 more
doaj   +1 more source

Impact of Atrial Fibrillation on the Risk of Thrombosis and Bleeding for Patients With Polycythemia Vera and Essential Thrombocytosis in the Real World

American Journal of Hematology, EarlyView.
Rodrigo Ortega Perez, Luis Manuel Domínguez Rodríguez, Francisca Ferrer‐Marín, Beatriz Cuevas Ruíz, Clara Martínez Valverde, Patricia Vélez Tenza, María Isabel Mata Vázquez, Adrián Segura Díaz, María Laura Fox, Elvira Mora, Manuel Mateo Pérez Encinas, Mercedes Gasior Kabat, Gonzalo Carreño‐Tarragona, Rafael Andrés del Orbe, Gonzalo Caballero‐Navarro, Elena Magro Mazo, Ana Pardo Sanz, José Luis Zamorano Gómez, Alberto Álvarez Larrán, Valentín Garcia‐Gutierrez   +19 more
wiley   +1 more source

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, EarlyView.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source