Results 51 to 60 of about 520,129 (244)

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer:5-year results for local control and overall survival from the TARGIT-a randomised trial [PDF]

, 2014
Background: The TARGIT-A trial compared risk-adapted radiotherapy using single-dose targeted intraoperative radiotherapy (TARGIT) versus fractionated external beam radiotherapy (EBRT) for breast cancer.
Holtveg, Helle M R, Tobias, Jeffrey S., Alvarado, Michael, Harris, Eleanor, Joseph, David J, Vaidya, Jayant S., Sütterlin, Marc, Vaidya, Jayant S, Flyger, Henrik L., Tobias, Jeffrey S, Massarut, Samuele, Falzon, Mary, Holtveg, Helle R, Brew-Graves, Chris, Dewar, John, Pigorsch, Steffi, Potyka, Ingrid, Bulsara, Max, Thompson, Alastair, Saunders, Christobel, Holtveg, Helle M. R., Joseph, David J., Roncadin, Mario, Keshtgar, Mohammed, Baum, Michael, Metaxas, Marinos, Dewar, John A, Flyger, Henrik, Eiermann, Wolfgang, Matthews, April, Brown, Douglas, Dewar, John A., Joseph, David, Williams, Norman R, Flyger, Henrik L, Williams, Norman R., Wenz, Frederik, Corica, Tammy, Esserman, Laura, Sperk, Elena   +39 more
core   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

Proton beam radiotherapy in the management of uveal melanoma: clinical experience in Scotland [PDF]

, 2008
<p>Aim: To evaluate proton-beam radiotherapy (PBRT) in the management of uveal melanoma in Scotland.</p> <p>Methods: A retrospective review was undertaken on all patients receiving PBRT for uveal melanoma (1994–2005).
McConnachie, A., Alex Taylor, Alex Kacperek, Aziz, S., Samir Aziz, Kemp, E., Andrzej McConnachie, Ewan Kemp, Kacperek, A., Taylor, A.   +9 more
core   +1 more source

Current Status and Future Perspectives of Robotic Surgery for Esophagogastric Cancer in Asia

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Robotic‐assisted surgery (RAS) has moved from an experimental adjunct to an increasingly established component of gastrointestinal (GI) oncological practice in parts of Asia, a region that carries a disproportionately high burden of gastric and esophageal cancer. Asian surgeons have been among the earliest and most prolific contributors to the
Jia Jun Ang, Jimmy Bok Yan So
wiley   +1 more source

A Feasibility of Respiration Prediction Based on Deep Bi-LSTM for Real-Time Tumor Tracking

IEEE Access, 2018
In radiotherapy, the position of thoracic-abdominal tumor is changing due to respiratory motion. Real-time tracking of thoracic-abdominal tumors is of great significance in improving the treatment effect of radiotherapy.
Ran Wang, Xiaokun Liang, Xuanyu Zhu, Yaoqin Xie   +3 more
doaj   +1 more source

Giovanni Antonio Scopoli's De Hydrargyro Idriensi Tentamina (1761): Mercury Mining, Mercurialism, and Preventive Reasoning in Eighteenth‐Century Occupational Medicine

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Giovanni Antonio Scopoli (1723–1788), a physician‐naturalist of the Enlightenment, is primarily remembered for his contributions to botany and entomology. Less attention has been paid to his medical work De hydrargyro Idriensi Tentamina physico‐chymico‐medica (1761), written during his fifteen years of service as physician at the mercury mines
Alberto Zanatta, Paola Mason, Sofia Bollini, Giovanni Magno   +3 more
wiley   +1 more source

Innervation of the tubarial glands: A hypothesis‐driven anatomical review

The Anatomical Record, EarlyView.
Abstract The tubarial glands have been described as a macroscopic bilateral glandular complex in the posterolateral nasopharynx near the torus tubarius and the pharyngeal opening of the Eustachian tube. Since their recognition on prostate‐specific membrane antigen‐based imaging, their anatomical classification has remained debated, with converging ...
Mugurel Constantin Rusu, Ivan Varga, Răzvan Costin Tudose   +2 more
wiley   +1 more source

Cardiac arrhythmias during and after thoracic irradiation for malignancies

Cardio-Oncology
Background Cardiac arrhythmia has been reported as a significant complication of thoracic radiotherapy. Both bradyarrhythmias and tachyarrhythmias have been reported, highlighting the arrhythmia-modulating potential of radiation in certain oncologic ...
Markus B. Heckmann, Jan P. Münster, Daniel Finke, Hauke Hund, Fabian Schunn, Jürgen Debus, Christine Mages, Norbert Frey, Ann-Kathrin Rahm, Lorenz H. Lehmann   +9 more
doaj   +1 more source

Innovative regression model-based decision support tool for optimizing radiotherapy techniques in thoracic esophageal cancer

Frontiers in Oncology
BackgroundModern radiotherapy exemplified by intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT), has transformed esophageal cancer treatment. Facing challenges in treating thoracic esophageal cancer near vital organs,
Yuxing Li, Yue Ke, Xinran Huang, Ruijuan Zhang, Wanghui Su, Hongbing Ma, Pu He, Xinyue Cui, Shan Huang   +8 more
doaj   +1 more source