Results 161 to 170 of about 3,114,604 (362)
Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury
Advanced Science, EarlyView.This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng +10 more
wiley +1 more source
Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment
Advanced Science, EarlyView.Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr. +20 more
wiley +1 more source
Role of video-assisted thoracic surgery in T4 NSCLC [PDF]
, 2021 Debora Brascia +8 more
openalex +1 more source
Advanced Science, EarlyView.Integrating spatial transcriptomics and single‐cell RNA sequencing, this study identifies a novel subpopulation of SLPI⁺ AT2‐like cells at the invasive margin of lung adenocarcinoma (LUAD). These cells, through stromal crosstalk and Wnt pathway activation, promote tumor stemness and invasion.
Zhoufeng Wang +13 more
wiley +1 more source
Nationwide Survey of the Surgical Treatment for Hiatal Hernia in Japan
Annals of Gastroenterological Surgery, EarlyView.This nationwide study of 960 hiatal hernia surgeries in Japan found that patients with Type I hernia had distinct characteristics and more favorable surgical outcomes compared to Types II–IV. Postoperative dysphagia was significantly associated with Types II–IV, preoperative dysphagia, and esophageal strictures, highlighting the need for careful ...
Soji Ozawa +8 more
wiley +1 more source
Minimally Invasive Esophagectomy for Esophageal Cancer: Current Evidence and Future Perspectives
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Aim Esophageal cancer is a highly aggressive malignancy with regional variations in histological subtypes. Adenocarcinoma predominates in Western countries, whereas squamous cell carcinoma is more common in Asia. Despite advances in multimodal therapy, esophagectomy remains the cornerstone of curative treatment, and the development of various ...
Hirotaka Konishi +3 more
wiley +1 more source