Results 111 to 120 of about 16,338 (322)

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Reliable AI Platform for Monitoring BCI Caused Brain Injury and Providing Real‐Time Protection

Advanced Science, EarlyView.
BrainGuard enables real‐time and interpretable assessment of brain injury caused by brain computer interface (BCI). Using feature‐based Gaussian process (GP) emulators trained on limited biomechanical data, it efficiently predicts full‐field strain and constructs patient‐specific digital brain twins to support clinical diagnosis and long‐term BCI ...
Chufan He, Yanjun Ding, Timon Rabczuk, Chensen Ding   +3 more
wiley   +1 more source

A century of oil and gas exploration in Albania: assessment of Naturally Occurring Radioactive Materials (NORMs)

, 2015
Because potential Naturally Occurring Radioactive Materials (NORMs) generated from oil and gas extractions in Albania have been disposed without regulatory criteria in many decades, an extensive survey in one of the most productive regions (Vlora-Elbasan)
Baldoncini, Marica, Callegari, Ivan, Colonna, Tommaso, Hasani, Fadil, Kaçeli, Merita Xhixha, Mantovani, Fabio, Shala, Ferat, Strati, Virginia, Xhixha, Gerti   +8 more
core   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Rapid Determination of Th(IV) in Thorium Dioxide Solution by Arsenazo III

Journal of Isotopes
ThO2 can produce many nuclides after accelerator bombardment, such as Actinium-225, Radium-223, Molybdenum-99, Iodine-131, Strontium-90, etc. There are many methods for measuring heavy elements such as thorium, but most of them are complicated to operate.
ZHAO Pengfei, WU Jiuwei, WANG Yu, LI Yong, GUAN Guoying
doaj   +1 more source

Gas core reactors for actinide transmutation and breeder applications [PDF]

This work consists of design power plant studies for four types of reactor systems: uranium plasma core breeder, uranium plasma core actinide transmuter, UF6 breeder and UF6 actinide transmuter. The plasma core systems can be coupled to MHD generators to
Clement, J. D., Rust, J. H.
core   +1 more source

Determination of Trace Levels of Uranium and Thorium in High Purity Gadolinium Sulfate Using ICP-MS with Solid-Phase Chromatographic Extraction Resin

, 2017
The new Super-Kamiokande-Gadolinium (SK-Gd) project is an upgrade of the Super-Kamiokande (SK) detector. In the SK-Gd project, 0.2\% Gd$_2$(SO$_4$)$_3$ is loaded into the 50 kton water tank of the SK.
Ikeda, M., Ito, S., Kishimoto, Y., Takaku, Y.   +3 more
core   +1 more source

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

Advanced Science, EarlyView.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang   +12 more
wiley   +1 more source

Future of superheavy element research: Which nuclei could be synthesized within the next few years?

, 2012
Low values of the fusion cross sections and very short half-lives of nuclei with Z$>$120 put obstacles in synthesis of new elements. Different nuclear reactions (fusion of stable and radioactive nuclei, multi-nucleon transfers and neutron capture), which
Alexander Karpov, Düllmann Ch, Hofmann S, Morita K Morimoto K, Oganessian Yu, Panov I V Korneev I Yu, Rosswog S Liebendoörfer M Thielemann F-K, Simenel C, Thompson T A Burrows A, Valeriy Zagrebaev, Walter Greiner, Zagrebaev V, Zagrebaev V, Zagrebaev V, Zagrebaev V I, Zagrebaev V I   +15 more
core   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source