Results 161 to 170 of about 2,984,231 (308)

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Ventral pallidum GABA neuron inhibition augments context-appropriate defensive responses to learned threat cues. [PDF]

Neurobiol Stress
Ramirez EM, Martinez MX, Rokerya RK, Vera VA, Ruiz CM, Farrell MR, Walawalkar SA, Ramirez-Ramirez H, Kollman GJ, Mahler SV.   +9 more
europepmc   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Changes in firearm intentions and behaviors after the 2024 United States presidential election. [PDF]

Inj Epidemiol
Anestis MD, Bond AE, Burke KC, Altikriti S, Semenza DC.   +4 more
europepmc   +1 more source

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

The impact of health literacy on treatment adherence in COPD patients: chain mediation roles of self-efficacy and perceived disease threat. [PDF]

Front Public Health
Wang F, Qian Y, Tian L, Cui Y.
europepmc   +1 more source

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

The Development of Trait Anxiety in Nonhuman Primates During the First Year of Life. [PDF]

Dev Sci
Puralewski R, Aggarwal N, Oler JA, Roseboom PH, Parkins L, Riedel MK, Boettcher C, Kalin NH.   +7 more
europepmc   +1 more source

From Grave to Cradle: Kombucha Waste for Sustainable Electronics

Advanced Science, EarlyView.
This study introduces a sustainable method to purify kombucha bacterial cellulose (KBC) with sodium bicarbonate and hydrogen peroxide, avoiding harsh chemicals. KBC films are patterned with gold and function as pressure sensors for flatfoot gait detection. At the end‐of‐life, the KBC‐based device biodegrades in soil, leaving environmentally benign gold
Xin Ying Chan, Xiaolu Sun, Eddy Yi Ler Pang, Iris Zhiyu Ren, Xuan Zhang, Pengyu Chen, Yu Jun Tan   +6 more
wiley   +1 more source

Effects of height-induced postural threat on static and dynamic balance performance in healthy individuals: a systematic review with meta-analysis. [PDF]

Front Hum Neurosci
Wissmann AM, Muehlbauer T, Hill MW.
europepmc   +1 more source