Results 141 to 150 of about 425,804 (302)

Long‐Term Follow Up of Two Patients With Variants in the Cluster 1031‐1159 of TRRAP Gene: Expanding the Phenotype of Developmental Delay With or Without Dysmorphic Facies and Autism

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The transformation/transcription domain‐associated protein (TRRAP) gene encodes a large multidomain protein, a member of the phosphatidylinositol 3‐kinase‐related kinase (PIKK) family. TRRAP is a component of the histone acetyltransferase (HAT) complex, and it plays an important role in gene transcription, DNA repair, and cell‐cycle regulation.
Roseli Maria Zechi‐Ceide, Vinicius Contrucci Dantas Segarra, Siulan Vendramini‐Pittoli, Henrique Regonaschi Serigatto, Luiza Virmond, Heloisa Marcelina da Cunha Palhares, Fernanda Jehee, Ana Cristina Victorino Krepischi, Carla Rosenberg, Carlos Henrique Paiva Grangeiro, Nancy Mizue Kokitsu‐Nakata   +10 more
wiley   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Are threatened species special? An assessment of Dutch bees in relation to land use and climate. [PDF]

Ecol Evol, 2023
Moens M, Biesmeijer JC, Klumpers SGT, Marshall L.   +3 more
europepmc   +1 more source

Animal models of chronic thromboembolic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
Current animal models of CTEPH. Created using BioRender.com. Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, yet life‐threatening disorder characterized by persistent pulmonary vascular obstruction and elevated pulmonary artery pressure, with progressive remodeling and subsequent right heart failure.
Yong‐Jian Zhu, Lin‐Chao Zhou, Xiao‐Xue Zhang, Xiao‐Yang Ren, Yi Yan, Shao‐Fei Liu   +5 more
wiley   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Anthropogenic impacts on threatened species erode functional diversity in chelonians and crocodilians. [PDF]

Nat Commun, 2023
Rodríguez-Caro RC, Graciá E, Blomberg SP, Cayuela H, Grace M, Carmona CP, Pérez-Mendoza HA, Giménez A, Salguero-Gómez R.   +8 more
europepmc   +1 more source

DNA barcode reveals occurrence of threatened species and hidden diversity on Teleost fish trade in the Coastal Amazon. [PDF]

Sci Rep, 2023
Santana P, Martins T, Lutz Í, Miranda J, da Silva R, Mesquita D, Martins R, Veneza I, Vallinoto M, Sampaio I, Evangelista-Gomes G.   +10 more
europepmc   +1 more source

Linking life history to landscape for threatened species conservation in a multiuse region. [PDF]

Conserv Biol, 2023
Shaw RE, Spencer PB, Gibson LA, Dunlop JA, Kinloch JE, Mokany K, Byrne M, Moritz C, Davie H, Travouillon KJ, Ottewell KM.   +10 more
europepmc   +1 more source

Accelerometry reveals limits to use of an energy-saving anthropogenic food source by a threatened species: A case of Carnaby's cockatoos (Zanda latirostris) and canola. [PDF]

Ecol Evol, 2023
Riley KJ, Warren K, Armstrong N, Yeap L, Dawson R, Mawson PR, Saunders DA, Cooper CE, Shephard JM.   +8 more
europepmc   +1 more source

Valuing the benefits from preserving threatened native fauna and flora from invasive animal pests [PDF]

Invasive animal pests inflict many kinds of damage on the environment, and threaten native fauna and flora. We attempt to value the benefits from the extra biodiversity that is protected if these threats were removed. The NSW Rural Lands Protection Board
Gong, Wendy, Jones, Randall E., Sinden, Jack A.   +2 more
core   +1 more source