Results 191 to 200 of about 45,988 (293)

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto   +7 more
wiley   +1 more source

Determinants of maximal oxygen uptake in highly trained females and males: a mechanistic study of sex differences using advanced invasive methods

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The results from this study show that maximal cardiac output, stroke volume and leg blood flow are similar between highly trained females and males after normalisation to lean body mass (LBM). However, the 10% higher haemoglobin concentration ([Hb]) and arterial O2 content in males result in higher systemic and leg O2 delivery ...
Øyvind Skattebo   +11 more
wiley   +1 more source

Impact of the right ventricular mechanical pattern assessed by three-dimensional echocardiography on adverse outcomes following cardiac surgery. [PDF]

open access: yesSci Rep
Keller M   +10 more
europepmc   +1 more source

4D ultrasound reveals regional left atrial strain remodelling in a murine model of reversible pressure overload

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Traditional planar imaging approaches of the left atrium do not capture complex geometry. Four‐dimensional imaging allows the acquisition of 3D data + time to visualize left atrial geometry and kinematics. We designed an advanced analysis technique to investigate left atrial biomechanics in a model of pressure overload and ...
John P. Salvas   +3 more
wiley   +1 more source

Long‐term passive heat acclimation enhances maximal oxygen consumption via haematological and cardiac adaptation in endurance runners

open access: yesThe Journal of Physiology, EarlyView.
Abstract Figure Legend Endurance‐trained runners completed a 5‐week hot‐water‐immersion (HWI) intervention (≥40°C, 45 min, five sessions per week) and a training‐matched control period in a cross‐over design. HWI induced a 33 g increase in haemoglobin mass (Hbmass) and a 10 mL expansion in left‐ventricular end‐diastolic volume (LVEDV), resulting in a 2.
Elliott J. Jenkins   +7 more
wiley   +1 more source

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