Results 61 to 70 of about 767,122 (251)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Effect of variation of charge in the circular restricted three-body problem with variable masses
Journal of Taibah University for Science, 2019 In the present paper, we are concerned by some investigation on circular restricted three-body problem (CR3BP), where we assume that the primaries have variable masses and variable charges. Among the principal tools used in the present study, we cite the
Abdullah Abduljabar Ansari +3 more
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Albedo-Induced Perturbation in the Sitnikov Three-Body Problem
PhysicsIn this paper, the circular Sitnikov three-body problem is studied under the combined influence of radiation pressure and albedo. The model consists of two equal-mass primaries moving in circular orbits about their center of mass and an infinitesimal ...
M. Shahbaz Ullah +2 more
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Three bodies, no problem [PDF]
Nature Reviews Physics, 2019 The three-body problem is relevant for astrophysical phenomena such as black hole mergers. It famously lacks a general analytical solution, but a new statistical solution relates the distributions of final and initial states, while requiring fewer assumptions than previous approaches.
openaire +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Canceling Effects of Conjunctions Render Higher-order Mean Motion Resonances Weak
The Astrophysical JournalMean motion resonances (MMRs) are a key phenomenon in orbital dynamics. The traditional disturbing function expansion in celestial mechanics shows that, for coplanar systems at low eccentricities, p : p − q MMRs exhibit a clear hierarchy of strengths ...
Elizabeth K. Jones +3 more
doaj +1 more source