Results 41 to 50 of about 4,005,719 (292)

Quasi-periodic Solutions of the Spatial Lunar Three-body Problem [PDF]

, 2013
By application of KAM theorem to Lidov-Ziglin's global study of the quadrupolar approximation of the spatial lunar three-body problem, we establish the existence of several families of quasi-periodic orbits in the spatial lunar three-body problem.Comment:
Zhao, Lei
core   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Gravitational Radiation Damping and the Three-Body Problem

, 2002
A model of three-body motion is developed which includes the effects of gravitational radiation reaction. The radiation reaction due to the emission of gravitational waves is the only post-Newtonian effect that is included here.
Bennet, Blanchet, Cameron, Chicone, Chicone, Chicone, Chicone, Chicone, Landau, Lyne, Schott, Stairs, Zachary E. Wardell   +12 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Dynamical Structures under Nonrestricted Hierarchical Planetary Systems with Different Mass Ratios

The Astronomical Journal
Secular dynamics have been extensively studied in both the inner and outer restricted hierarchical three-body systems. In the inner restricted problem, the quadrupole-order resonance (i.e., the well-known Kozai resonance) causes large coupled ...
Xiumin Huang, Hanlun Lei
doaj   +1 more source

Analytic Understanding of the Resonant Nature of Kozai–Lidov Cycles with a Precessing Quadrupole Potential

The Astrophysical Journal Letters, 2023
The very long-term evolution of the hierarchical restricted three-body problem with a slightly aligned precessing quadrupole potential is studied analytically.
Ygal Y. Klein, Boaz Katz
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

General Relativistic Effect on Sitnikov Three-Body Problem: Restricted Case

Astronomy
We investigate the effect of general relativity on the Sitnikov problem. The Sitnikov problem is one of the simplest three-body problems, in which the two primary bodies (a binary system) have equal mass m and orbit their barycenter, while the third body
Hideyoshi Arakida
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

O pluralismo da tese dos três mundos de Popper e a crítica de Habermas [PDF]

Princípios, 2006
The present study approaches the three world thesis (TWT), by Karl Popper. The TWT as pluralist and interactionist opposes to monism and some dualist conceptions.
João Batista C. Sieczkowski
doaj