Results 51 to 60 of about 766,122 (253)

The Three-Body Problem and the Shape Sphere

open access: yesThe American Mathematical Monthly, 2015
27 pages, 8 figures, submitted to American Math ...
openaire   +2 more sources

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Spin Three-Body Problem of Classical Electrodynamics with Radiation Terms (I) Derivation of Spin Equations

open access: yesResults in Nonlinear Analysis, 2021
In the present paper spin equations for three-body problem of classical electrodynamics are introduced. They should be considered jointly with 3-body equations of motion derived in a previous paper of the author.
Vasil G. Angelov
doaj   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Effect of variation of charge in the circular restricted three-body problem with variable masses

open access: yesJournal of Taibah University for Science, 2019
In the present paper, we are concerned by some investigation on circular restricted three-body problem (CR3BP), where we assume that the primaries have variable masses and variable charges. Among the principal tools used in the present study, we cite the
Abdullah Abduljabar Ansari   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Albedo-Induced Perturbation in the Sitnikov Three-Body Problem

open access: yesPhysics
In this paper, the circular Sitnikov three-body problem is studied under the combined influence of radiation pressure and albedo. The model consists of two equal-mass primaries moving in circular orbits about their center of mass and an infinitesimal ...
M. Shahbaz Ullah   +2 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

open access: yesFEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Home - About - Disclaimer - Privacy