Results 121 to 130 of about 4,311 (162)

A newly discovered <i>Aerococcus urinae</i> mediates transfer of the pCF10 plasmid via SPI-WT regulation. [PDF]

Front Microbiol
Zhang M, Yang X, Li R, Qian J, Hao R, Xu L, He Q, Shen Z, Wang J, Zhu Y, Qiu Z.   +10 more
europepmc   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

The bHLHzip-type transcription factor, <i>MaHpa3</i>, regulates conidial rodlet formation and cell surface hydrophobicity in the insect fungal pathogen <i>Metarhizium acridum</i>. [PDF]

Virulence
Song D, Yan X, Xie S, Guo G, Cao Y, Xia Y.   +5 more
europepmc   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Biomarker-targeted functionalized magnetic nanoparticles: synthesis and aptamer conjugation optimization toward Alzheimer's disease biosensing. [PDF]

Nanoscale Adv
Makridis A, Kazeli K, Katsipis G, Tzekaki EE, Pantazaki AA, Bosch C, Simon-Carbajo R, Angelakeris M.   +7 more
europepmc   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

INDETERMINATE DOMAIN 9 negatively regulates rice crown root development. [PDF]

Front Plant Sci
Yang Y, Shi Z, Nie X, Meng Y, Chu Z, Zou W, Jian Q, Zhu D, Zhang T.   +8 more
europepmc   +1 more source

Majority‐Voting Overlapping Method for Error Correction in DNA Data Storage

Advanced Intelligent Discovery, EarlyView.
We propose an overlapping‐based majority‐voting method for DNA data storage error correction. By aligning multiple reads and choosing the most frequent base per position, it suppresses substitution errors without prior models. Validated on synthetic and real sequencing data, it achieves high‐fidelity, scalable, and cost‐effective reconstruction ...
Thi Bich Ngoc Nguyen, Seongjun Seo, Anshula Tandon, Nguyen Kim Uyen, Thi Hong Nhung Vu, Sung Ha Park   +5 more
wiley   +1 more source

A 3'UTR polymorphism disrupts IRF2BP2 autoregulation through an eIF4H translational enhancer. [PDF]

Front Genet
Duong A, Chen HH, Stewart AFR.
europepmc   +1 more source