Results 61 to 70 of about 18,657,891 (347)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

LCCT‐derived three‐level three‐phase inverters

IET Power Electronics, 2017
Solutions for a family of the novel three‐level neutral‐point‐clamped (NPC) inductor‐capacitor‐capacitor‐transformer (LCCT)‐derived three‐phase inverters are described and compared. Component design guidelines and steady state analysis, current and voltage waveforms are given. The authors’ simulation results confirm the theoretical predictions.
Shults, Tatiana, Husev, Oleksandr, Blaabjerg, Frede; id_orcid 0000-0001-8311-7412, Zakis, Janis, Khandakji, Kamal   +4 more
openaire   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Analysis of Output Current Ripple of Three-phase PWM Inverter under Discontinuous Modulation Techniques [PDF]

, 2010
In this paper, an analysis of output current ripple of three-phase PWM inverters with discontinuous modulation is presented. The analytical expressions for discontinuous modulation injection signal are derived.
Dahono, Pekik Argo
core  

An improved SVPWM control algorithm for three-level inverter

Journal of Measurement Science and Instrumentation, 2017
In the traditional three-level space vector pulse width modulation（SVPWM）algorithm,the sector judgment is computationally complex since the sector is divided into triangles and hexagons.In addition,the switching frequency is high because the seven ...
HUANG Xiao-feng, WANG Xiao-peng, SUN Chun-xia   +2 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Loss Analysis and Calculation for Three-level IGBT Inverter

Kongzhi Yu Xinxi Jishu, 2017
Taking three-level converter application as an example, this paper analysed the components and influence factors of heat loss of working IGBT, presented an approach to calculate the heat loss of IGBT in three-level converter by different control methods,
ZHU Wu, XIN Li, LI Yanyong, ZHANG Donghui   +3 more
doaj  

Shunt Active Power Filter with Three Level Inverter using Hysteresis Current Controllers [PDF]

E3S Web of Conferences
This document introduces a Shunt Active Power Filter (SAPF) for three-phase three-wire systems, utilizing a Cascaded H Bridge Multilevel Inverter. The Hysteresis Current Control technique provides numerous benefits, including simplicity, minimal current ...
Raghutu Ramakrishna, Manoj Vasupalli, Kumar Yegireddy Narendra   +2 more
doaj   +1 more source