Results 231 to 240 of about 3,116,587 (283)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Integrated pH-responsive three-phase system: Time- and solvent-efficient biorefining of <i>Camellia oleifera</i> waste into multifunctional saponins. [PDF]

Food Chem X
Chen Z, Fan J, Zhao C, Huang T, Guo Z, Qiu C, Deng J.   +6 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Exploring Burnout at the Morgue During the COVID-19 Pandemic: A Three-Phase Analysis of Forensic and Pathology Personnel. [PDF]

Healthcare (Basel)
Oprinca-Muja LA, Cristian AN, Topîrcean E, Cristian A, Popa MF, Cardoș R, Oprinca GC, Atasie D, Mihalache C, Bucuță MD, Morar S.   +10 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Modeling and analysis of 100 kW two-stage three-phase grid-connected PV generation system under absurd atmospheric and grid disturbances. [PDF]

PLoS One
Mohamed Hariri MH, Salem M, Mohd Jamil MK, Abdullah MN, Mat Desa MK.   +4 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Joint probabilistic modeling approach for harmonic and three-phase unbalanced disturbance sources. [PDF]

Heliyon
Ren Z, Chen XL, Wang C, Lan Y, Feng X.
europepmc   +1 more source

A novel dual hysteresis controller for the management of a three phase dynamic voltage restorer. [PDF]

Heliyon
V V, C P, I S.
europepmc   +1 more source

Retraction Note: Experimental design and analysis of advanced three phase converter for PV application with WCO-P&O MPPT controller. [PDF]

Sci Rep
Krishnaram K, Sivamani S, Alaas Z, Ahmed MMR, Senthilkumar S, Raj SA.   +5 more
europepmc   +1 more source