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CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Design and implement of high accuracy HV-CCPS for high power discharge pumped excimer laser. [PDF]

Sci Rep
Shen Q, Liang X.
europepmc   +1 more source

Wireless, passive inductor-capacitor sensors for biomedical applications. [PDF]

Med X
Xu B, Patel S, Yu C.
europepmc   +1 more source

Intelligent MPPT-based energy management for hybrid renewable energy grids using trans Z-source quadratic boost converter. [PDF]

Sci Rep
Manickam S, Padma S.
europepmc   +1 more source

High-power dual-channel chamber for high-frequency magnetic neuromodulation. [PDF]

J Neural Eng
Tian X, Wang H, Wang B, Zhang J, Yan D, Ingabire J, Coffler S, Duret G, Pham QK, Bao G, Wang J, Veeraraghavan A, Robinson JT, Goetz SM, Peterchev AV.   +14 more
europepmc   +1 more source

Maximizing wireless power transfer efficiency at exceptional points. [PDF]

Commun Eng
Hu WK, Zhang B, Hu Y, Li H, Han W.
europepmc   +1 more source

Design and Characterization of a Self-Oscillating Fluxgate-Based Current Sensor for DC Distribution System Applications. [PDF]

Sensors (Basel)
Chen W, Chen H, Xu H, Li L.
europepmc   +1 more source

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A Cascaded Coupled Inductor-Reverse High Step-Up Converter Integrating Three-Winding Coupled Inductor and Diode–Capacitor Technique

IEEE Transactions on Industrial Informatics, 2017
This paper introduces a cascaded high step-up converter realized with a tightly coupled three-winding coupled inductor. Compared with existing high step-up converters, the proposed converter features that the smaller the turns ratio, the larger the conversion gain.
Fei Li, Hongchen Liu
openaire   +3 more sources