Results 51 to 60 of about 7,014 (289)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A tunable common mode inductor with an auxiliary winding network [PDF]

, 2015
Paper 1593Track no. 5 - Devices and ComponentsIn conventional switching converter, the parasitic capacitance between switching circuit and ground introduces common mode (CM) noise problem. A CM inductor is inserted in the power feeding paths to produce a
Kiratipongvoot, S, Lee, CK, Ng, WM, Pong, BMH, Xu, D   +4 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A High Step-Up Cost Effective DC-to-DC Topology Based on Three-Winding Coupled-Inductor

IEEE Journal of Emerging and Selected Topics in Industrial Electronics, 2023
Owing to the low voltage level that renewable energy sources like solar panels frequently provide, and limited capability of simple boost converter, need for high gain step-up dc-to-dc converters are increased. In this article a single switch high step-up dc-to-dc topology with high efficiency is developed.
Mohammad Farsijani, Sohrab Abbasian, Hossein Hafezi, Adib Abrishamifar   +3 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Study on a Trans-Inverse High Gain SEPIC-Based DC-DC Converter With ZCS Characteristics for Photovoltaic Applications

International Transactions on Electrical Energy Systems
This paper aims to propose, study, and implement a non-isolated trans-inverse high step-up SEPIC-based DC-DC converter for photovoltaic applications.
Mahdi Elmi, Mohamad Reza Banaei, Hadi Afsharirad   +2 more
doaj   +1 more source

High Voltage Step-Up Boost Converter Based on a Three-Winding-Coupled Inductor With Voltage Multiplier Cell

IEEE Access
The present paper endeavors to make a significant contribution to the field of high-voltage non-isolated dc-dc converters. This is achieved by utilizing a voltage multiplier cell based on the three-winding coupled inductor technique.
Carolina Albuquerque Caldeira, Mario Lucio da Silva Martins, Marcelo Cabral Cavalcanti, Antonio Dutra Dantas de Almeida, Eduardo Augusto Oliveira Barbosa, Leonardo Rodrigues Limongi   +5 more
doaj   +1 more source

Effective control of the error in a direct measurement of core-loss power [PDF]

, 1995
Accuracy of a direct measurement of core-loss power is severely limited in many applications by the extra phase shift between the measured voltage and current.
Tan, F. Dong, Vollin, Jeff L., Ćuk, Slobodan   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Miniature implantable instrument measures and transmits heart function data [PDF]

, 1971
Heart diameter is derived from measured transit time of 2.25 MHz ultrasonic pulse between two piezoelectric crystals attached to diametrically opposite heart surfaces.
Lee, R. D.
core   +1 more source